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Hello Everyone! Welcome to Periodic UHC Season 5, Boron!

This UHC is organized by TehBaconBrawlerZ, and in this season we will be doing a Rigged Team of 3 using the following scenarios:

Scenarios:

Anti-Boronics: Boronic Acid is used for tons of of Pharmaceutical Methods in the real world, and the same is true in the game! Combining 4 Glass, 2 Redstone, 1 Diamond, a Golden Apple and a Bottle, you can create a Tier 1 Anti-Boronic, and using the same craft again substituting the bottle for the Tier 1 Potion, will give you a Tier 2 Anti-Boronic. Upon drinking either tier, you will take damage and gain different effects, based on the Tier of Potion:
-Tier 1 Potion - 1.5 Hearts of Damage but gains Strength and Haste 1 for 30 Seconds. -Tier 2 Potiom - 3.5 Hearts of Damage but gains Strength 2 for 20 Seconds and Speed 1 for 15 seconds.
Boronic Armor: Boron is a key component in types of Armor, such as Bulletproof Vests and Tank Armor. Because of this, players are unable to enchant their equipment past basic level enchantments provided by the enchanting table (no anvils). Instead, in order to make higher tier gear, they have to combine the piece of equipment with different items (Iron, Gold, Diamonds, Feathers, Arrows and Apples). Inspiration was taken from (and given permission by) Elunial, organizer of "The Saga"
^{*Bold = Highlighted}

Team	Link
ashley lavacasts AGAIN	-
AshleyMashley	Episode 1
DefectiveSickle	Episode 1
KatyLawson	Episode 1
spec favorites	-
PhoenixTheViking	Episode 1
Stevenator0808	Episode 1
ZebraTonic	Late
any they/thems tryna lemme feel they/tiddies	-
nishimarii	Combined with Ep 2
LoserSky_	Episode 1
JimmyJawns	PC Wiped POV
The British	-
78ford	Episode 1
Xzeaulor	I Feel Inadequate
draylor09	Episode 1
The Sacrifice	-
FalingDutchman	Episode 1
SugarIsZoey	Episode 1
fruitlogic	Episode 1
TheGreat Nick Nuggets	-
Blufferfish2009	Episode 1
CharityTheGreat	Late
nug17	Late
fellas doing fella things	-
1Rag	Episode 1
crazyblue19	Episode 1
Ullti	Aja
loud	-
K0REDRAG0N	Episode 1
NikoAnimation	Late
Zapnic	Episode 1
comedy club	-
CommanderK22_	Episode 1
Jervy_Ras	Episode 1
ProMapleSyrup	Non-Recorder
gang plank	-
BuildingBard300	Episode 1
Jalapinecone	Lost
Mathgeek007	Episode 1
The JEGS	-
jimmyjegs	Lost?
Rockall	Episode 1
EmNoJo	Non-Recorder
The Winning Team	-
MattChills	Lost Footage
Scrub72	Non-Recorder
Omnixkrxn	Episode 1
Irony	-
Jahrod	Episode 1
Nyxbee	PC Exploded
Buzzy_Bee_120	Episode 1
Irony 2	-
KaeBTW	Late
Ghaosty	Episode 1
TehBaconBrawlerZ	Episode 1
Spec	-
_Fost_	Episode 1
Rohcket	Episode 1

Death Tracker

Position	Player	Team Color	Cause	Episode Link
42nd	???	???	???	???
41st	???	???	???	???

Previous Episodes

• Intro

Credits

• Organization - TehBaconBrawlerZ
  
• Host/Coding - TheSlimeBrother
  
• Intro - Kirbey
  
• Art - Ghaosty
  
• Logo - Forgot_N
  

We are into June, and still can't say with certainty, precisely where we are at.
Therefore, I'll propose, that the next conference call shall announce only that all responses have been finalized to the final deciding authority. I don't believe that CytoDyn will announce any response of the authority, since, none has been given, only that everything has been recently submitted to them, that is what I'm thinking. The webcast should also discuss the situation with Cyrus. Everybody sitting here reading this knows that what is happening isn't normal; that what is going on in the world and that which is going on here just ain't right. We can't just keep on being tone deaf to all of it, just ignoring it as it happens or pretending that it is all normalcy.
Therefore, I truly do appreciate all those who do post the studies on CCR5 and CCL5 and what the effects are of allowing and / or disallowing this chemical inter-cellular communication to and / or from happening. These studies go a long way into deciphering, unveiling and understanding the truth about this immunoregulatory communication cascade. I feel like these are akin to rays of light that shoot across the din of darkness where much is spoken, but little is said and even less heard. Most of the vast deluge of information is of minimal consequence, but the information discussing this cellular communication signal, really is of massive consequence.
For example, take this shooting star for instance: Barriers between Anti-CCR5 Therapy, Breast Cancer and Its Microenvironment and take note perrenialloser, these authors are not Chinese: by Elizabeth Brett , Dominik Duscher , Andrea Pagani , Adrien Daigeler , Jonas Kolbenschlag , Markus Hahn .
Many things are included in the article, but these are only a snippet:
"CCL5 is a potent chemokine with a physiological role of immune cell attraction and has gained particular attention in R&D for breast cancer treatment. Its receptor, CCR5, is a well-known co-factor for HIV entry through the cell membrane. Interestingly, biology research is unusually unified in describing CCL5 as a pro-oncogenic factor, especially in breast cancer. In silico, in vitro and in vivo studies blocking the CCL5/CCR5 axis show cancer cells become less invasive and less malignant, and the extracellular matrices produced are less oncogenic. At present, CCR5 blocking is a mainstay of HIV treatment, but despite its promising role in cancer treatment, CCR5 blocking in breast cancer remains unperformed.
As with all other forms of cancer, prognosis is strongly influenced by the clinical stage at which the cancer is diagnosed. The later the cancer is diagnosed, the more likely it is that the patient will not recover from the disease.
By acting as a classical chemotactic cytokine for T cells, eosinophils, basophils and other cells, CCL5 recruits leukocytes to the site of inflammation, induces proliferation of NK cells and is an HIV-suppressive factor released from CD8+ T cells. The receptor with the highest affinity for CCL5 is the CC motif chemokine receptor 5 (CCR5), being mainly expressed in T cells, smooth muscle endothelial cells, epithelial cells and parenchymal cells. The CCL5/CCR5 interaction facilitates inflammation, adhesion and migration of T cells in immune responses. CCR5 is involved in chronic diseases, cancers and COVID-19 infection.
There is a wealth of evidence showing that CCL5 is co-opted in breast cancer and in many other types of tumors, such as pancreatic, ovarian, prostate and glioma cancer. In vitro and in vivo tests show that blocking or knocking down CCL5/CCR5 is detrimental to tumors such breast cancer and limits metastases. The possibility of targeting the CCL5/CCR5 axis and inducing an antitumor environment is therefore real but challenging. However, a CCR5 blocker that can be part of cancer therapy has yet to be developed.
As introduced before, CCL5 is an extremely powerful chemoattractant with a physiologic role in recruiting immune cells in inflammatory or allergic circumstances CCL5 binds with high affinity to its main receptor CCR5, but also to CCR1, -3, -4, CD44 and GPR75. CCR5 is a seven-transmembrane G-protein-coupled receptor expressed on various cell types, such as T cells, macrophages, dendritic cells, eosinophils and microglia. The interaction between CCR5 and its high-affinity molecules (e.g., CCL5, CCL3, CCL4 and CCL8) results in G protein activation and a following boost of different signal transduction pathways. One of these is represented by NF-kB (Nuclear Factor kappa-light-chain-enhancer), in which CCL5 represents an important target gene.
As mentioned before, the CCL5/CCR5 interaction facilitates cancer progression through several different mechanisms. CCL5/CCR5 interaction increases tumor dimensions, induces ECM remodeling, increases cellular migration and metastasis formation, supports cellular stemness and expansion along the tumor borders, confers on cancer cell resistance to therapies, decreases DNA damage, deregulates cellular energetics (metabolic reprogramming), promotes angiogenesis, recruits immune and stromal cells and induces the immunosuppressive polarization of macrophages.
There is an unmatched level of evidence supporting the participation of all chemokines other than CCL5 in the construction, development and operation of the primary invasive breast tumor. CCL5 is also ubiquitous across breast cancer cases, being present at stages I, II and III, and over 95% of triple-negative breast tumors are CCR5+.
Belonging to a different pharmacological family, Leronlimab is a humanized igG4k monoclonal antibody also able to bind CCR5. Adams et al. recently reported some clinical trials testing Leronlimab in metastatic TNBC patients. The phase 1b/2 dose escalation (NCT03838367), Compassionate Use (NCT04313075) and the Basket Study (NCT04504942) were pooled in order to evaluate the drug’s safety and efficacy at 12 months. After the analysis of 28 metastatic TNBC patients, the authors showed that Leronlimab has significant antitumor activity. The clinical trials suggest that metastatic TNBC patients dosed with Leronlimab have a real clinical benefit with improved 1-year progression-free and overall survival and few treatment-emergent adverse events. Finally, after exploring the effect of Leronlimab on circulating tumor-associated cells (TACs) from peripheral blood, the authors revealed that Leronlimab resulted in a drop in circulating TACs in the majority of patients correlating with early therapy response.
Within the tumor, cancer cells secrete CCL5 and sustain the proliferation of CCR5-positive cells, recruit T-regulatory cells and monocytes, cause osteoclast activation and bone metastasis, neo-angiogenesis and cancer cells dissemination. CCR5 is therefore overexpressed in breast, head, neck, gastric, esophageal, pancreatic and prostate cancer, colorectal carcinoma, melanoma, Hodgkin’s lymphoma, acute lymphocytic leukemia and other tumors. In the clinical setting, higher cytoplasmic CCR5 staining and CCR5 receptor levels correlate with poor prognosis in breast cancer and gastric adenocarcinoma patients. Even elevated levels of its main ligand CCL5 indicate poor prognosis in breast, cervical, prostate, ovarian, gastric and pancreatic cancer and metastatic colorectal carcinoma."
---
But here is the bit of light only we who have those polarized sun glasses can appreciate. On 12/7/22, Cyrus puts forth CytoDyn's Plans to get Leronlimab to market. Essentially, it is the Investor Deck, filed with the SEC and it lays out his game plan for bringing Leronlimab to the people. One of the main problems with this prognostic plan is that share holders can not see it unfolding. The reason for this is that the #1 Priority of this plan is to get the clinical hold on Leronlimab Lifted. This process is shielded from shareholder sight. The other problem is that many of the remaining goals of the Investor Deck are dependent on meeting the 1st goal, the #1 priority. Therefore, they too are shielded from shareholder's view. Therefore, shareholder's can's see the plan unfolding.
This is what Cyrus said, " "9:25: We expect next year, 2023 to be catalyst driven in terms of growth and development for the company and we think that the table is set for a large number of significant developments to occur in early '23, including the submission of our complete response to the partial clinical hold for HIV, new additions to the leadership team, a corporate rebranding, and then following those events, we plan on initiating a NASH trial as well as continuing the advancement of the long acting CCR5 molecule."
However, along the way, Cyrus has thrown us a bone or two and has given us some peeks as to what is happening and proof that things are in fact unfolding as he said they would. We have learned the name of the re-branding, LivImmune. There has recently been new additions to the leadership team, Melissa Palmer, MD as new CMO and Salah Kivlighn, PhD, Clinical & Strategic Advisor. By bringing on Melissa Palmer, MD Hepatologist, it can not be said any clearer that NASH is in the near future and CytoDyn's number one clinical indication. Cyrus has been saying that NASH would be monotherapy and wouldn't be combination therapy. We know that CytoDyn can not do it alone, it is too small. We can take a little deeper look and see that Dr. Palmer has a history with TAKeda pharmaceuticals. "Dr. Palmer left Kadmon in 2015 to become Global Lead on Shire's NASH program, as well as other liver-related issues within the company, such as orphan cholestatic liver diseases PFIC Alagilles, PSC and PBC, and liver-related safety issues (DILI), and was rapidly promoted to Global Development Lead - Hepatology and led the formation of the liver safety group. Shire was acquired by Takeda in 2019 at which time Dr. Palmer was recruited as Head of Liver Disease Development at Takeda." TAK has TAK-647 which is: " Ontamalimab is a fully human immunoglobulin G2 monoclonal antibody against mucosal addressin cell adhesion molecule-1 which failed phase 3 clinical trials for ulcerative colitis (UC) and Chrons Disease, but now is in Phase 1 clinical trials for NASH."
Prior to these we had: "12:56: We have also firmly established Dr. Scott Hansen as our Head of Research and Basic Science. Dr. Hansen is currently an Associate Professor at OHSU. and within this newly formalized role, Dr. Hansen will support our clinical development activities, related to biomarker and assay development for future clinical trials, as well as supporting and leading some of our earlier staged efforts, geared towards the development of longer acting molecules targeted to CCR5."
We learned that CytoDyn "13:33: has also recently entered into a joint development agreement with a 3rd party Research and Development Bio-Tech company to develop long acting or more longer acting molecule CCR5 blocking.
It goes without saying that CytoDyn needs help. CytoDyn has 4 different plays, and each play is devoid of a sufficient data pool which would draw in funding for that indication. Cyrus' long term goal expressed in the Investor Deck is to build out a strong enough clinical trial data pool to present it to a partner or a buyer. So then, without any cash of our own, Cyrus' plan is to have someone else's funding, partner with CytoDyn and build for us that data pool and in the end, have exactly those same partners compete for the entirety of the resultant conglomerate, for the whole or for a part once that data pool is firmly in hand.
The same story goes for HIV-Prep and HIV-Cure which is likely being run by the 3rd party Research and Development Bio-Tech company Vir, in collaboration to develop the long acting or a more longer acting molecule of CCR5 blockade. Vir is pretty much a given with Scott Hansen's strong connections there, but I remain skeptical due to the mechanism of action of VIR 1388 working to phagocytose HIV itself by initiating T Cells to target HIV epitopes while LL blocks CCR5. This was kept secret, but somewhat hinted at by Cyrus in the 4/11/23 Webcast .
We can apply the same logic in the Oncology study being run by MD Anderson using Merck's Keytruda in combination with Leronlimab. We had all been waiting to find out what had happened with the results of the MD Anderson study, and Cyrus threw us this line: "Leronlimab is currently being trialed in combination with Keytruda (pembrolizumab) in a breast cancer xenograft model in partnership with MD Anderson Cancer Center." From here, he gave us a hint of what is to come.
It can be assumed that as these collaborations are officially announced, that is, after the hold is lifted, that there shall be share price inflection. In his astute fashion, Cyrus has given us the secrets, has only threw us some bones, but, because of the strange times we live in, and because CytoDyn has not yet met Priority #1, the share price has not yet moved.
The only thing the market "sees" is the fact that the hold hasn't yet been lifted. They are "Blinded by the Light". The shooting stars grace the night sky, but nobody sees them, because everyone is blinded by the fact that the hold hasn't yet been lifted. Clothed by the blinding light, made tone deaf by the din of bewildering and unnecessary information. They say nothing else matters unless the hold is lifted and that is what share price is saying. Nothing else matters. Nobody even reads articles on CCR5/CCL5, they are meaningless without Priority #1 being met. That is what the market says. But what does the Fox say?
That's the point though, to use this as a blinding distraction and it is working. How else do the other Priorities get put into place, if there wasn't something put in place to distract from the construction? Of course, a clinical hold provides all the blinders necessary to construct partnerships within, without disclosure of their assembly. We can be assured, that everything Cyrus put together in that Investor Deck is happening. Maybe, not exactly as he said it would. Surely, he did not count on his getting sick, but, these things happen and he will recover and get right back on it, assuredly. Cyrus gave us that plan, so we can know what is happening despite the blinding light, despite the din of confusion that would be taking place in the proximal future ahead of that Investor Deck presentation which is taking place right now. He knew, that had he not provided those prognostic words, shareholders today would be blinded, but he gave us the plan, so we could see. The Investor Deck was free of charge, yet it was prognostic. It would have been impossible to see what is happening today, had it not been for that R & D Update then. We therefore can see the events unroll as they happen which lead to the goals he has set forth there in, as we have been witnessing them happening. That Deck was crucial for our understanding. Many of us have been pointing to that Deck, but no one more so than u/Upwithstock .
When the hold lifts, the blinders will be removed and all eyes shall be opened. Until then, only ours who have heard and understand that Investor Deck know what is happening now. All others remain blind to all of which is happening. They think it is all doom and gloom, but we know, that the Investor Plan is going forward. It is not a co-incidence that Cyrus told us all these things before this long period of waiting began. Long stents of time providing hardly any information. But when information did come, it was telling of the plan unfolding. Cyrus was saying, "Don't worry, the plan is going forward." So, he got sick, but there was a backup plan and likely, this was announced in a way he wasn't planning, but it was Plan B and he had our backs regardless and there wasn't even a set back. Cyrus will be back soon, assuredly. So, we wait for him.
How much hotter will it get? Hopefully, we get a webcast soon and I think it will be indicating that all has been recently submitted. I also hope that they will announce when Cyrus returns back to his seat. My eyes are glued to every detail that happens and how it correlates with the Investor Deck. It was given to us as shareholders, so lets stay focused on it and not be blinded. The sun is bright almost every day, but we are wearing special, polarized sun glasses. We will see that Deck unfold. Just hang on to your seats, because when it begins, it will happen quickly as it has been in the planning, design and soon to be rollout stages all the while. The triggering event approaches, and we know to look for it, so be ready.

TL;DR: convidei alguns amigos para beber em meu apartamento, mas fiquei preocupado com a questão do espaço pelo local ser pequeno. Mandei uma mensagem de áudio para um casal de amigos que eu já tinha convidado dizendo que talvez eles ficassem desconfortáveis pela falta de espaço e lugar para sentar, mas que podiam vir. O casal que recebeu o áudio interpretou que eu não queria que eles viessem. Alguns de meus amigos que já estavam comigo disseram que falei de uma forma babaca que parecia que eu não queria que eles viessem mesmo.
—----------------------------------
(Estou postando essa história por outra pessoa. O narrador seria essa outra pessoa, e eu, OP, sou um dos amigos que estava presente quando ela aconteceu)
Um amigo meu, que chamarei de Dourado, tinha comentado que estava afim de beber no fim de semana. Na sexta, falei com ele pra ver se ele e a namorada iriam querer beber de noite e ele disse que estava afim, mas que iria confirmar depois pois tinha alguns problemas de tarde pra resolver.
Convidei outros 3 amigos nossos em comum (amigos 3, 4 e 5), e avisei pro Dourado que iríamos beber no meu apartamento e que se desse pra ele vir era só ele aparecer. Nessa, meu amigo número 5, convidou um outro casal de amigos nossos também (amigos 6+7). Mencionei com o Amigo 5 que provavelmente não haveria lugar para todo mundo sentar, mas que por mim não tinha problema mesmo ficando meio cheio.
Um pouco depois, comecei a pensar mais no lance dos lugares e do espaço, pois caso o Dourado e a namorada dele viessem não teria lugar para todos sentarem. Em meu apartamento só tem espaço livre para nos reunirmos em meu quarto, que tem 1 cama e 3 cadeiras e tudo isso um pouco apertado. Como seríamos 7 pessoas no total, mesmo que 3 pessoas sentassem na cama só tem mais 3 cadeiras e faltaria lugar para uma pessoa sentar, tendo então que ficar em pé ou sentada no chão, o que também seria desconfortável pela falta de espaço no geral.
Pensando nisso, mandei um áudio explicando pro Dourado avisando que como tinham sido convidados mais 2 pessoas eu estava com receio quanto a questão do espaço. Não porque eu achava ruim eles virem, mas que eu não queria que eles (Dourado e namorada) ficassem desconfortáveis, o que também ia me deixar desconfortável por eles não estarem bem no meu apê. Falei que se eles decidissem vir de qualquer jeito que era pra eles trazerem 2 cadeiras pra eles poderem sentar de boa (nessa hora já não tinha mais como eu arranjar outras cadeiras).
Depois estava no apartamento com os amigos 3/4/5 e chegaram o casal 6+7 e ficamos bebendo. Depois de um tempo sem resposta do Dourado, fiquei achando que ele e a namorada só tinham desistido de vir por não conseguirem terminar mais cedo o serviço deles, mas então meu Amigo 5 disse que tinha recebido uma mensagem do Dourado com ele meio puto falando que eu tinha mandado um áudio “desconvidando” ele e a namorada com a desculpa de que não queria que o apartamento ficasse cheio.
Achei besteira isso, pois só tinha mandado um áudio explicando a situação pra ele, e que não era que eu não queria que ele e a namorada viessem, mas sim que eu estava preocupado com eles se sentirem desconfortáveis.
Pediram para que eu mostrasse o áudio para que eles pudessem opinar. Um de meus amigos disse que achou o que eu falei normal, que não ficou com a impressão que eu estava desconvidando ele, mas os outros disseram que no áudio parecia que eu preferiria que eles (Dourado e namorada) não viessem ao invés de parecer que eu estava preocupado com o conforto deles. O áudio em questão é esse: Link do áudio
Eu também comentei com quem estava no apartamento que eu não esperava que iria ter mais 2 pessoas, que foram as convidadas pelo meu amigo 5, mas o 5 disse que quando ele me falou que tinha convidado o casal 6+7 eu respondi sem parecer que ia ter algum problema, e que se eu tivesse demonstrado estar muito preocupado com a questão do espaço desde o começo tinha como ele (o 5) ter desconvidado esse outro casal sem problemas.
E ai, sou o babaca?

Buona sera, qui per chiedere pareri e consigli, ma soprattutto per condividere.
Allora ho 20anni, sono al primo anno e ho momenti di anedonia e depressione, non provo piacere, obbiettivi e emozioni in nessun caso.
Allora, al Uni mi son trovato bene ed è ben organizzata, ma purtroppo la mia ADHD sta rendendo tutto di una difficolta enorme, sto pensando di chiedere un anno di pausa.
Pure se prescritto di farmaci, non riesco a studiare, studio una cazzo di pagina in un ora.
Sinceramente, io penso che questa condizione se insieme al anedonia, rende la vita una merda, nel vero senso che non riesci a essere positivo pure se cerchi di cambiare, di essere seguito da specialisti, che ti prescrivono i farmaci, niente.. non posso vedere un film ne fare qualunque attività, non posso impegnarmi e pure se sto ore e ore sui libri vado lento come una lumaca pure con i farmaci nel cervello.
Sinceramente sto pensando che non vale la pena vivere una vita del genere e che qualunque pro e cosa positiva nel futuro, non potrà mai levarmi l'ADHD, ok ma gia quella è difficile, ma l' anedonia... cazzo, probabilmente ti invalida la tua esistenza in generale nel mondo e il tuo senso di esistenza... vivere essendo piatti e vuoti e senza provare nulla in qualunque caso, fa schifo.
Io ci sto riflettendo su, perchè soffrire con farmaci, TMS, elettro shock e qualunque cazzo di cosa per poi avere una vita comunque difficile, senza che tu ne hai colpe, non è il massimo.
Nella mia vita non ho mai avuto stabilita e mai mi son sentito al pari o felice come gli altri, purtroppo sono stato sfortunato dalla genetica, e non posso cambiare il mio cervello e come è sviluppato.
Per ora mi sembra abbastanza, se mi verrà altro aggiungerò
EDIT-1 : sono seguita da una psichiatra con un percorso farmacologico [ritalin, antidepressivo] da due mesi, ho anche il supporto psicologico di uno psicologo.

Hello people, long story short I want to build a pc with a 1000$ budget. Here is a list of my chosen parts. Let me know what I should change.
CPU: Intel Core i3-13100F 3.4 GHz Quad-Core Processor Motherboard: MSI PRO B660M-E DDR4 Micro ATX LGA1700 Motherboard Memory: Klevv CRAS X RGB 32 GB (2 x 16 GB) DDR4-3600 CL18 Memory Storage: Corsair MP600 CORE XT 1 TB M.2-2280 PCIe 4.0 X4 NVME Solid State Drive Video Card: Sapphire PULSE Radeon RX 6750 XT 12 GB Video Card Case: *Corsair 4000D Airflow ATX Mid Tower Case Power Supply: Corsair RM750x (2021) 750 W 80+ Gold Certified Fully Modular ATX Power Supply

Hello people, long story short I want to build a pc with a 1000$ budget. Here is a list of my chosen parts. Let me know what I should change.
CPU: Intel Core i3-13100F 3.4 GHz Quad-Core Processor Motherboard: MSI PRO B660M-E DDR4 Micro ATX LGA1700 Motherboard Memory: Klevv CRAS X RGB 32 GB (2 x 16 GB) DDR4-3600 CL18 Memory Storage: Corsair MP600 CORE XT 1 TB M.2-2280 PCIe 4.0 X4 NVME Solid State Drive Video Card: Sapphire PULSE Radeon RX 6750 XT 12 GB Video Card Case: *Corsair 4000D Airflow ATX Mid Tower Case Power Supply: Corsair RM750x (2021) 750 W 80+ Gold Certified Fully Modular ATX Power Supply

Buona sera, qui per chiedere pareri e consigli, ma soprattutto per condividere.
Allora ho 20anni, sono al primo anno e ho momenti di anedonia e depressione, non provo piacere, obbiettivi e emozioni in nessun caso.
Allora, al Uni mi son trovato bene ed è ben organizzata, ma purtroppo la mia ADHD sta rendendo tutto di una difficolta enorme, sto pensando di chiedere un anno di pausa.
Pure se prescritto di farmaci, non riesco a studiare, studio una cazzo di pagina in un ora.
Sinceramente, io penso che questa condizione se insieme al anedonia, rende la vita una merda, nel vero senso che non riesci a essere positivo pure se cerchi di cambiare, di essere seguito da specialisti, che ti prescrivono i farmaci, niente.. non posso vedere un film ne fare qualunque attività, non posso impegnarmi e pure se sto ore e ore sui libri vado lento come una lumaca pure con i farmaci nel cervello.
Sinceramente sto pensando che non vale la pena vivere una vita del genere e che qualunque pro e cosa positiva nel futuro, non potrà mai levarmi l'ADHD, ok ma gia quella è difficile, ma l' anedonia... cazzo, probabilmente ti invalida la tua esistenza in generale nel mondo e il tuo senso di esistenza... vivere essendo piatti e vuoti e senza provare nulla in qualunque caso, fa schifo.
Io ci sto riflettendo su, perchè soffrire con farmaci, TMS, elettro shock e qualunque cazzo di cosa per poi avere una vita comunque difficile, senza che tu ne hai colpe, non è il massimo.
Nella mia vita non ho mai avuto stabilita e mai mi son sentito al pari o felice come gli altri, purtroppo sono stato sfortunato dalla genetica, e non posso cambiare il mio cervello e come è sviluppato.
Per ora mi sembra abbastanza, se mi verrà altro aggiungerò
EDIT-1 : sono seguita da una psichiatra con un percorso farmacologico [ritalin, antidepressivo] da due mesi, ho anche il supporto psicologico di uno psicologo.

Hello people, long story short I want to build a pc with a 1000$ budget. Here is a list of my chosen parts. Let me know what I should change.
CPU: Intel Core i3-13100F 3.4 GHz Quad-Core Processor Motherboard: MSI PRO B660M-E DDR4 Micro ATX LGA1700 Motherboard Memory: Klevv CRAS X RGB 32 GB (2 x 16 GB) DDR4-3600 CL18 Memory Storage: Corsair MP600 CORE XT 1 TB M.2-2280 PCIe 4.0 X4 NVME Solid State Drive Video Card: Sapphire PULSE Radeon RX 6750 XT 12 GB Video Card Case: *Corsair 4000D Airflow ATX Mid Tower Case Power Supply: Corsair RM750x (2021) 750 W 80+ Gold Certified Fully Modular ATX Power Supply

The Form
LAPTOP QUESTIONNAIRE

• Total budget (in local currency) and country of purchase. Please do not use USD unless purchasing in the US: 3500-4500 PLN (Poland), i.e. around $850 - $1000
• Are you open to refurbs/used? Preferably not
• How would you prioritize form factor (ultrabook, 2-in-1, etc.), build quality, performance, and battery life? build quality (durability) > performance > battery life > form factor
• How important is weight and thinness to you? It should be thin and light, nothing more than ~1,75 kg
• Do you have a preferred screen size? If indifferent, put N/A. I'd prefer 15', but 13,3' can be fine
• Are you doing any CAD/video editing/photo editing/gaming? List which programs/games you desire to run. I will mainly do backend programming so will use VSCode, but besides that, I also use e.g. Android Studio (together with Android Virtual Device); Except for programming, I'll use Photoshop and Premiere Pro.
• If you're gaming, do you have certain games you want to play? At what settings and FPS do you want? I won't be playing any games on the laptop, I've got a PC for that
• Any specific requirements such as good keyboard, reliable build quality, touch-screen, finger-print reader, optical drive or good input devices (keyboard/touchpad)? Good keyboard (since I'll be programming) and decent touchpad, if possible 2 USB inputs and HDMI (not necessary but I'd love to have them)
• Leave any finishing thoughts here that you may feel are necessary and beneficial to the discussion. I'm thinking of choosing:
  • MacBook Air M1 8/256 - but I'm wondering if it's worth it + I'd have to buy the USB hub/adapter + limited software support
  • Lenovo ThinkBook 15 G4 IAP 15,6" i5-1235U 16/512

I've never had a MacBook before, but would probably enjoy using macOS. I don't have an iPhone.

Atualmente a minha rotina se resume à, estudar das 7:00 as 12:00, chegar em casa, fazer almoço, arrumar a casa, ir trabalhar as 14:00 sair do trampo as 22:00, fazer janta, arrumar tudo pro dia seguinte e dormir as 23:00. Sou um adolescente e o resto dos meus amigos e amigas não compartilham de uma rotina semelhante, antes de começar a trabalhar eu tinha vários amigos e etc etc, entretanto agora estou completamente sozinho, a semanas não converso com uma única pessoa além da minha família e colegas de trabalho. Me sinto sozinho e cansado por conta da minha rotina e consequências da mesma, e claramente sair do meu emprego ou parar de estudar não é uma opção. E quando chegam os finais de semana estou cansado demais ou tenho obrigações para cumpir.
(Por favor não comentem coisas como "não eram seus amigos de verdade!" afinal, se coloquem no lugar deles, você manteria a amizade com alguém que simplesmente não tem um minuto pra te responder? alguém que você não vê e não conversa? é como manter amizade com um presidiário, você só vai o ver em dias de visita, no caso, raros finais de semana.)

Bom, que isso é comum todo mundo já sabe, torto pra cima, prum lado, pro outro... Porém o que eu não sei é se isso atrapalha ou gera algum desconforto na hora da penetração, do oral, ou se simplesmente não faz diferença.
Gostaria que vocês, que tem experiência com pênis dessem a sua opinião aqui, para tirar a minha dúvida e a de outros tb, por favor.

ta tendo obra aqui em casa, ai pro cachorro não ficar pisando no cimento prendemos ele na coleira, ele tem mais ou menos 1 ano e meio, o fato é que ele fica chorando e não para, oq posso fazer?

I'm quite new to diy drones, and am looking for some advice on what cameras I should use. I am aware that premade solutions such as DJI drones exist, but I am specifically looking for advice if I go down the diy route (treating this more as a fun project than just looking for the end result). The drones primary purpose would be for taking pictures/videos, likely of landscapes.
Here is what I would like from the cameras:

• Streaming to a flatscreen device (likely phone or raspberry pi). Stream does not have to be very high quality or low latency, as this will not be used for racing or tricks.
• Ability to start/stop recordings and take pictures while flying. I would like this to be reasonably high quality with little to no editing afterward.
• Relatively affordable and small (i.e. not mounting a full DSLR camera). I'm fine with spending a few hundred dollars.

A few options I have seen online/considered:

• Small FPV camera + higher quality camera (e.g. GoPro). I'm not sure if there is a good way to stream the fpv to a flatscreen instead of goggles. Also not sure how to control the GoPro remotely (start/stop video and take pictures). Slightly annoying having a different stream from what the pictures will be as I won't know exactly what I am taking a picture of.
• FPV/HD camera. I have seen options like the runcam split. Solves the problem of having multiple cameras, but still not sure about streaming to flatscreen or remotely controlling. Also doesn't seem to be as good of picture quality.

What my ideal solution would look like:

• Relatively small camera with pretty good quality (like a GoPro) that can stream video to phone/computer (relatively high latency/low quality is fine) and can be controlled remotely.

Again, I am aware that if I was just looking to get the best drone for the money buying something like the DJI Mini 3 would probably be my best option, but I would like to build it myself. Does anyone have any recommendations for how I could accomplish this? Thanks for any guidance.

​
https://preview.redd.it/xbbmvwk05y2b1.jpg?width=1280&format=pjpg&auto=webp&s=116c1a4c80219604524cc4a321c8086cdb93a5a7
if ANYONE is interested send me a message on Fiverr
==> https://bazarcom.org/Biahezacourse
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Hi all,
I'm looking to seriously upgrade my home audio system. I almost exclusively listen to Spotify (but will upgrade to Tidal), but I also love vinyl and have building up my collection over the past 6 years (~100 records), so I hope to start listening much more to vinyl once I have this new system.
Budget and location - Ideally around $15k but if $20k would make a significant improvement, I could be convinced. I live in the Boston area.
How the gear will be used - Home audio in a designated, medium-sized room that'll serve as my music/library room (no theatre; never owned a TV).
New or used - only interested in new gear, as I'm a huge proponent of "but-it-for-life" (I realize I may upgrade select components once every 3-5 years). But generally for all purchases (not just audio), I like to over-research for the initial purchase, take extensive notes, then enjoy not having to think about repairs/upgrading for as long as possible.
Past gear experience - Currently own an entry-level system due to existing space constraints and budget, neither of which are constraints anymore. Specifically, I'm using:

• turntable: Orbit Custom; Walnut wood, cue lever, acrylic platter, ortofon 2M red ($460)
  
• receiver: Onkyo TX-8270 Stereo Network A/V Receiver ($450)
  
• passive speakers: Klipsch Reference Premiere RP-5000F 2-way Floorstanding Speaker ($650 for the pair)
  
• subwoofer: SVS PB-2000 Pro Series ($1000), which is my most recent purchase. I know this is overkill for my current speakers; I purchased this subwoofer to be the first piece of my upcoming complete rehaul of the system.
  

Current Considerations I am considering the following pieces of gear but would love to hear other suggestions, too:

• turntable
  
  • Rega Planar 8 w/ Apheta 3 MC Cartridge ($5k)
  • Technics Direct Drive SL-1210G-K without cartridge ($4.3k)
  • ClearAudio Concept AiR w/ MC Cartridge ($2.9k)
• network player
  
  • Naim ND5 XS2 Slim Chassis Network Player ($4k)
  • Cambridge Audio CXN V2 Network Player ($1k)
• integrated amp
  
  • Pass Labs INT-25 ($7.6k)
  • McIntosh MA5300 ($6k)
  • Yamaha A-S2200 ($4.5k)
  • Rotel RA-6000 Diamond Series ($4k)
  • Parasound Halo HINT 6 ($2.8k)
• speakers
  
  • Klipsch Heritage Forte IV ($5k)
  • Wharfedale Elysian 4 ($5k)
• subwoofer
  
  • keep my current SVS PB-2000 Pro Series 12" ($1k)

Question #1: Given that I'll be listening to Tidal ~80% of the time, and vinyl ~20% of the time, am I considering the correct components, or should I change things? (e.g., not an integrated amp but a pre-amp and power amp)
Question #2: Do you have any suggestions for other items to consider? Of these components, I've mostly researched speakers and amps, and it seems the Forte IV's and Pass Labs' amps are highly acclaimed by many
Question #3: Please let me know, specifically, which items you'd select (not restricted to my considered items above) to create a system for ~$15k - $18k
Also, I gladly welcome any other general tips or suggestions. For example, I have a pretty extensive plan to blind test ~4 pieces, tournament style, once I've narrowed down 2 options for 2 separate key components (e.g., 2 speakers and 2 amps).
Thanks, all!

2023-06-03T17:13:31 Notice opnsense /interfaces.php: plugins_configure dns (execute task : unbound_configure_do()) 2023-06-03T17:13:31 Notice opnsense /interfaces.php: plugins_configure dns (execute task : dnsmasq_configure_do()) 2023-06-03T17:13:31 Notice opnsense /interfaces.php: plugins_configure dns () 2023-06-03T17:13:31 Error opnsense /interfaces.php: The command '/bin/kill -'TERM' '9755'' returned exit code '1', the output was 'kill: 9755: No such process' 2023-06-03T17:13:31 Notice opnsense /interfaces.php: plugins_configure dhcp (execute task : dhcpd_dhcp_configure()) 2023-06-03T17:13:31 Notice opnsense /interfaces.php: plugins_configure dhcp () 2023-06-03T17:13:31 Notice opnsense /interfaces.php: plugins_configure ipsec (execute task : ipsec_configure_do(,wan)) 2023-06-03T17:13:31 Notice opnsense /interfaces.php: plugins_configure ipsec (,wan) 2023-06-03T17:13:30 Notice opnsense /interfaces.php: plugins_configure monitor (execute task : dpinger_configure_do(,WAN_DHCP6)) 2023-06-03T17:13:30 Notice opnsense /interfaces.php: plugins_configure monitor (,WAN_DHCP6) 2023-06-03T17:13:30 Error opnsense /interfaces.php: ROUTING: not a valid default gateway address: '' 2023-06-03T17:13:30 Notice opnsense /interfaces.php: ROUTING: configuring inet6 default gateway on wan 2023-06-03T17:13:30 Notice opnsense /interfaces.php: ROUTING: entering configure using 'wan' 2023-06-03T17:13:29 Notice kernel <6>ng0: changing name to 'pppoe1' 2023-06-03T17:13:29 Notice kernel WARNING: attempt to domain_add(netgraph) after domainfinalize() 2023-06-03T17:13:29 Notice kernel <6>mlxen0: link state changed to UP 2023-06-03T17:13:29 Error opnsense /interfaces.php: The command '/ussbin/ngctl msg 'mlxen0': setautosrc 1' returned exit code '71', the output was 'ngctl: send msg: No such file or directory' 2023-06-03T17:13:25 Notice configctl event @ 1685808804.78 exec: system event config_changed 2023-06-03T17:13:25 Notice configctl event @ 1685808804.78 msg: Jun 3 17:13:24 OPNsense.techlocal config[27247]: config-event: new_config /conf/backup/config-1685808804.7686.xml 2023-06-03T17:08:33 Notice kernel <6>mlx4_en: mlxen0: Link Down