4860 bethesda ave bethesda md 20814
[MD] Bethesda, Cumberland, trail tour, camping, C&O Canal Towpath, in the next few weeks
2023.06.06 18:15 toaster404 [MD] Bethesda, Cumberland, trail tour, camping, C&O Canal Towpath, in the next few weeks
Can start at either end. Was planning on getting car ride to Cumberland, then riding back.
I'm also doing a shakedown within the next week from N. Va. to whatever camp I reach in a day and back.
submitted by toaster404 to BikeBuddies [link] [comments]
I'm also doing a shakedown within the next week from N. Va. to whatever camp I reach in a day and back.
2023.06.06 16:15 PritchettRobert506 [HIRING] 25 Jobs in MD Hiring Now!
2023.06.06 13:45 mattykens48 [REQ] ($275) - (#Bethesda, MD, USA) (Repay $325 on 6/15)
Just looking for a $275 loan, $325 to be repaid by 6/15. I have a fair amount of history :) I would prefer Zelle/Cashapp/Venmo if possible as I have been having problems with PayPal. I really appreciate it, thanks y’all!
submitted by mattykens48 to borrow [link] [comments]
2023.06.05 17:05 Tanen7 Question about practical armors or sleeving armors
I’m going to go back to vanilla armors for most things for this LO. I’ve used NWUA for everything for sometime and I want to change it up. I’m using snipeys amidianborn book of silence
https://mods.bethesda.net/en/skyrim/mod-detail/4329712
I like armor variety though. So i have added armor variants expansion
https://mods.bethesda.net/en/skyrim/mod-detail/4153506
I’ve also added practical armors
https://mods.bethesda.net/en/skyrim/mod-detail/4095629
I’ve noticed some of the armors doesn’t have sleeves, are the variations added in AVE not affected by practical armors? Would sleeving Skyrim be any different?
https://mods.bethesda.net/en/skyrim/mod-detail/4021293
submitted by Tanen7 to SkyrimModsXbox [link] [comments]
https://mods.bethesda.net/en/skyrim/mod-detail/4329712
I like armor variety though. So i have added armor variants expansion
https://mods.bethesda.net/en/skyrim/mod-detail/4153506
I’ve also added practical armors
https://mods.bethesda.net/en/skyrim/mod-detail/4095629
I’ve noticed some of the armors doesn’t have sleeves, are the variations added in AVE not affected by practical armors? Would sleeving Skyrim be any different?
https://mods.bethesda.net/en/skyrim/mod-detail/4021293
2023.06.05 05:26 fiftythreestudio Experimental redesign of the Washington Metro map [oc]
![Experimental redesign of the Washington Metro map [oc]](https://preview.redd.it/r64lj0itf24b1.png?width=640&crop=smart&auto=webp&s=5018cae232a3f9addbd721b2a1ec18956d2a68c6 "Experimental redesign of the Washington Metro map [oc]") | submitted by fiftythreestudio to TransitDiagrams [link] [comments] |
2023.06.04 23:04 fiftythreestudio washington metro map redesign, by me. this one did not make the cut for the book.
| | submitted by fiftythreestudio to lostsubways [link] [comments] |
2023.06.04 18:28 non_trad_student Washington DC/Bethesda MD truly hot spots?
Hello my friends.
I am wondering if you can please let me know about hot spots in the greater Washington DC metro area, as well as toward Bethesda, if possible.
I am looking for stores that sell interesting (i.e., tasty/fragrant/pleasantly pungent or super hot) sauces, marinades, pastes, seasoning blends etc... Also, I am wonder if there are any excellent pepper markets, in terms of diversity of peppers and extremeness too. I am specifically looking for the "super hots" like ghost peppers, Carolina reapers, and Trinidad scorpions, and so on. I am looking for them fresh if any farmers markets have them.
Lastly, does anyone know incredibly spicy restaurants or with unique spicy challenges in Bethesda or in the greater DC metro area.
Thank you if you are able to help!
submitted by non_trad_student to spicy [link] [comments]
I am wondering if you can please let me know about hot spots in the greater Washington DC metro area, as well as toward Bethesda, if possible.
I am looking for stores that sell interesting (i.e., tasty/fragrant/pleasantly pungent or super hot) sauces, marinades, pastes, seasoning blends etc... Also, I am wonder if there are any excellent pepper markets, in terms of diversity of peppers and extremeness too. I am specifically looking for the "super hots" like ghost peppers, Carolina reapers, and Trinidad scorpions, and so on. I am looking for them fresh if any farmers markets have them.
Lastly, does anyone know incredibly spicy restaurants or with unique spicy challenges in Bethesda or in the greater DC metro area.
Thank you if you are able to help!
2023.06.03 20:26 toddles84 Brain Cancer and The Alcoholic Caretaker
It started during Covid like I’m sure it has for many others, but I think the seeds of my alcoholism and depression were planted well before then. Covid just gave me the opportunity to realize and reflect that my life is headed nowhere except, perhaps, to an early grave.
The story starts about a year into what has been the longest relationship of my life. We met in April 2018 and I fell in her love with her, and I still feel the same, but something’s changed within me that’s not allowing me to find happiness anymore in my life. I could probably write a novel about my experience of being a caretaker to someone with brain cancer, but I’ll try to spare you of all the details as this will already be lengthy.
When we met, we were in our early thirties. Well, she was in her early thirties. I was in my mid-thirties. We were young, at least younger than we are now. We were vibrant and full of energy. She told me early in the relationship that she had what’s called an anaplastic ependymoma, a rare type a brain cancer. It was obviously important to her to let me know that she had this medical condition, as I’m sure it would scare off some romantic partners. Now at the time and on the surface, you wouldn’t have been able to tell she had cancer. But it didn’t scare me away as I simply asked, “Well, you’re not going anywhere, are you?” She said no and that was enough for me to continue with the relationship.
She moved into my house about 5 months into the relationship and about a month later I got a phone call while I was on a business trip telling me that the tumour had grown and that she was going to receive a procedure called a laser ablation. Up until that point in my life when she first told me, cancer was very foreign to me in the sense that I hadn’t experienced living with a loved one that had any form of cancer.
Over the years, we’ve endured so many surgeries. I couldn’t even count the amount she’s had anymore. We went through laser ablations, craniotomies, stereotactic radiosurgeries, compounded with treatment after treatment, chemotherapies, and immunization therapies.
In December 2019, she again had a reoccurrence. The Oncology and Neurosurgeon teams advised that another craniotomy was the best route to go. Unfortunately, after this one, she lost mobility on the left side of her body rendering her hemiplegic because of where the little fucking bastard grows. She spent about a little over a month recovering in an inpatient rehab facility. I would often stay the night to keep her company and sleep on what I would describe as the stiffest and starchiest couch I have ever sat on in my life. When she was released, we returned home and she began outpatient rehab therapy and, we as the supportive couple that we are, really focused in on getting her able to walk again and eating healthy. Of course, by this time Covid brought the whole fucking world to a screaming halt and I had ample time to assist in her recovery.
And wouldn’t you know it! We accomplished our goal. She never has, nor will she ever again have full mobility, but with the assistance of an AFO (Ankle/Foot Orthotic) she was able to walk well enough, but not very fast or very long distances. So we planned a trip to Michigan’s Upper Peninsula and it was spectacular! Even though it wasn’t always easy getting around, we managed and created some of the happiest moments of my life together. I think my favourite was pulling her around Mackinaw Island using a rickshaw. However, right before our trip, she went in for an MRI. Once again, the fucking asshole had to rear its ugly little head back into our lives, not that it ever left, but it would have been nice to have kept it from growing again so fast. So we set an appointment for yet another craniotomy to be performed in June 2020.
And I think that this was the time when things started to get really, really bad for me. I just remember coming home after the surgery while she recovered in the ICU with a 12 pack of Two Hearted Ale and just started crying and I couldn’t stop. For hours and hours on end, I just cried. Anyway, there were setbacks, but not quite on the same level as the December 2019 surgery. She returned home and continued with outpatient rehab and, some short time after, we learned about a clinical trial being performed at the NIH in Bethesda, MD.
Here we go! Hopefully, this is our golden ticket, and we can be rid of this thing once and for all. Due to Covid, I had the time on my hands to accompany her back and forth to the NIH, however, for her to receive the treatment, we would have to travel 3 weeks a month, every month until the completion of the trial.
I remember my eyes welling up from the commitment we had to make and thinking, ‘this is my life now.’ And that may sound selfish to you. And you might be right, but I knew in that moment, I had lost control of my own life knowing that I would have to sacrifice my wants, needs, and desires for someone else who just simply wants to live. The experience was mentally, emotionally, and financially draining, but it was worth it in the end to keep that hope alive. My girlfriend became friends with another girl there. She really makes friends everywhere she goes. Her new friend had Acute Myeloid Leukemia and, unfortunately, she passed away and I know that was especially hard. So from July 2020 to December 2020, we travelled back and forth to Maryland until the clinical trial was deemed a failure. All the while, I’m drinking more and more, and my mood and behaviour is becoming increasingly more erratic.
From 2021 through 2022, not much had changed. That is to say - it was more of the same. Doctors; surgeons; beer cans are piling up. She did get three elective surgeries. Two for a club foot release and a tendon release on her wrist, which are residual side effects from the number of surgeries she has had on her brain. In October 2022, another laser ablation.
Now we’re in January 2023. The surgical scar from the ablation did not heal properly. The skin on the top of her scalp had been stretched so thin that you could see the titanium screws implanted in her head. The Neurosurgeon team told us that when hardware is visibly exposed as in this case, they must treat it as if there were an infection. The plan of action is to, once again, perform surgery in the form of a skin graft removing all the hardware, cleaning up the infection, and replacing it with unaffected hardware. It was close to a 12 hour surgery and all I could think about was escaping to get a beer.
We currently learned that there’s been regrowth once again. Due to the elective surgeries and the skin graft procedure, she’s been off any form of treatment for some time now, so it really didn’t come as a surprise to us. However, instead of surgery, the Oncologist recommends she returns to treatment by means of chemotherapy and a drug called Avastin, which is an anti-angiogenic that targets the source of tumour and in theory cuts off the blood supply feeding the little fucker. However, my girlfriend feels she wants to continue with another surgery on her foot because of the discomfort, which would prevent her from going on treatment and would result in another craniotomy. And over the past week, this sent me over the edge.
I understand that this is her choice. However, the route she’s decided to take has caused me so much stress and anxiety. I mean just scheduling an MRI causes me to have PTSD. I told her that I cannot handle another surgery. We went through 5 surgeries in 8 months including the skin graft operation.
And this is the part that sucks. I think we’re finished. There’s too many stressors in my life that’s causing me to repeat a vicious cycle. I’m tired of pretending to be strong while crying in shadows. Do I get help from anyone? Not as much as her immediate family should. The father lives out of state and the mother thinks she’s a martyr for buying her a $7 gyro. As much as I love her and will always love her, I can’t do it anymore. I’ve sacrificed my happiness for her health and it’s honestly going to kill me. She told me I should go to therapy. I didn’t listen. I should have gone to therapy because now all I feel is regret, disgust, and resentment.
submitted by toddles84 to TrueOffMyChest [link] [comments]
The story starts about a year into what has been the longest relationship of my life. We met in April 2018 and I fell in her love with her, and I still feel the same, but something’s changed within me that’s not allowing me to find happiness anymore in my life. I could probably write a novel about my experience of being a caretaker to someone with brain cancer, but I’ll try to spare you of all the details as this will already be lengthy.
When we met, we were in our early thirties. Well, she was in her early thirties. I was in my mid-thirties. We were young, at least younger than we are now. We were vibrant and full of energy. She told me early in the relationship that she had what’s called an anaplastic ependymoma, a rare type a brain cancer. It was obviously important to her to let me know that she had this medical condition, as I’m sure it would scare off some romantic partners. Now at the time and on the surface, you wouldn’t have been able to tell she had cancer. But it didn’t scare me away as I simply asked, “Well, you’re not going anywhere, are you?” She said no and that was enough for me to continue with the relationship.
She moved into my house about 5 months into the relationship and about a month later I got a phone call while I was on a business trip telling me that the tumour had grown and that she was going to receive a procedure called a laser ablation. Up until that point in my life when she first told me, cancer was very foreign to me in the sense that I hadn’t experienced living with a loved one that had any form of cancer.
Over the years, we’ve endured so many surgeries. I couldn’t even count the amount she’s had anymore. We went through laser ablations, craniotomies, stereotactic radiosurgeries, compounded with treatment after treatment, chemotherapies, and immunization therapies.
In December 2019, she again had a reoccurrence. The Oncology and Neurosurgeon teams advised that another craniotomy was the best route to go. Unfortunately, after this one, she lost mobility on the left side of her body rendering her hemiplegic because of where the little fucking bastard grows. She spent about a little over a month recovering in an inpatient rehab facility. I would often stay the night to keep her company and sleep on what I would describe as the stiffest and starchiest couch I have ever sat on in my life. When she was released, we returned home and she began outpatient rehab therapy and, we as the supportive couple that we are, really focused in on getting her able to walk again and eating healthy. Of course, by this time Covid brought the whole fucking world to a screaming halt and I had ample time to assist in her recovery.
And wouldn’t you know it! We accomplished our goal. She never has, nor will she ever again have full mobility, but with the assistance of an AFO (Ankle/Foot Orthotic) she was able to walk well enough, but not very fast or very long distances. So we planned a trip to Michigan’s Upper Peninsula and it was spectacular! Even though it wasn’t always easy getting around, we managed and created some of the happiest moments of my life together. I think my favourite was pulling her around Mackinaw Island using a rickshaw. However, right before our trip, she went in for an MRI. Once again, the fucking asshole had to rear its ugly little head back into our lives, not that it ever left, but it would have been nice to have kept it from growing again so fast. So we set an appointment for yet another craniotomy to be performed in June 2020.
And I think that this was the time when things started to get really, really bad for me. I just remember coming home after the surgery while she recovered in the ICU with a 12 pack of Two Hearted Ale and just started crying and I couldn’t stop. For hours and hours on end, I just cried. Anyway, there were setbacks, but not quite on the same level as the December 2019 surgery. She returned home and continued with outpatient rehab and, some short time after, we learned about a clinical trial being performed at the NIH in Bethesda, MD.
Here we go! Hopefully, this is our golden ticket, and we can be rid of this thing once and for all. Due to Covid, I had the time on my hands to accompany her back and forth to the NIH, however, for her to receive the treatment, we would have to travel 3 weeks a month, every month until the completion of the trial.
I remember my eyes welling up from the commitment we had to make and thinking, ‘this is my life now.’ And that may sound selfish to you. And you might be right, but I knew in that moment, I had lost control of my own life knowing that I would have to sacrifice my wants, needs, and desires for someone else who just simply wants to live. The experience was mentally, emotionally, and financially draining, but it was worth it in the end to keep that hope alive. My girlfriend became friends with another girl there. She really makes friends everywhere she goes. Her new friend had Acute Myeloid Leukemia and, unfortunately, she passed away and I know that was especially hard. So from July 2020 to December 2020, we travelled back and forth to Maryland until the clinical trial was deemed a failure. All the while, I’m drinking more and more, and my mood and behaviour is becoming increasingly more erratic.
From 2021 through 2022, not much had changed. That is to say - it was more of the same. Doctors; surgeons; beer cans are piling up. She did get three elective surgeries. Two for a club foot release and a tendon release on her wrist, which are residual side effects from the number of surgeries she has had on her brain. In October 2022, another laser ablation.
Now we’re in January 2023. The surgical scar from the ablation did not heal properly. The skin on the top of her scalp had been stretched so thin that you could see the titanium screws implanted in her head. The Neurosurgeon team told us that when hardware is visibly exposed as in this case, they must treat it as if there were an infection. The plan of action is to, once again, perform surgery in the form of a skin graft removing all the hardware, cleaning up the infection, and replacing it with unaffected hardware. It was close to a 12 hour surgery and all I could think about was escaping to get a beer.
We currently learned that there’s been regrowth once again. Due to the elective surgeries and the skin graft procedure, she’s been off any form of treatment for some time now, so it really didn’t come as a surprise to us. However, instead of surgery, the Oncologist recommends she returns to treatment by means of chemotherapy and a drug called Avastin, which is an anti-angiogenic that targets the source of tumour and in theory cuts off the blood supply feeding the little fucker. However, my girlfriend feels she wants to continue with another surgery on her foot because of the discomfort, which would prevent her from going on treatment and would result in another craniotomy. And over the past week, this sent me over the edge.
I understand that this is her choice. However, the route she’s decided to take has caused me so much stress and anxiety. I mean just scheduling an MRI causes me to have PTSD. I told her that I cannot handle another surgery. We went through 5 surgeries in 8 months including the skin graft operation.
And this is the part that sucks. I think we’re finished. There’s too many stressors in my life that’s causing me to repeat a vicious cycle. I’m tired of pretending to be strong while crying in shadows. Do I get help from anyone? Not as much as her immediate family should. The father lives out of state and the mother thinks she’s a martyr for buying her a $7 gyro. As much as I love her and will always love her, I can’t do it anymore. I’ve sacrificed my happiness for her health and it’s honestly going to kill me. She told me I should go to therapy. I didn’t listen. I should have gone to therapy because now all I feel is regret, disgust, and resentment.
2023.06.03 15:32 blackknight1 DC Theatre Scene 23/24
Still some great shows this season (Sweeney Todd, Passing Strange at Signature; Exclusion at Arena; Good Bones and Fun Home at Studio) but below are links to next year’s season. Please post any theatres I missed!
Many of the theaters listed have discounts such as rush tickets, student tickets or pay what you can (usually the first week).
Lastly check out https://theatrewashington.org for all shows currently playing
Arena Stage (DC) - https://www.arenastage.org/tickets/2023-24-season/
Folger Theatre (DC) - https://events.folger.edu/packages/fixed/1315
Ford’s Theatre (DC) - https://fords.org/whats-happening/2023-2024-season
Keegan Theatre (DC) - not out yet but two shows left this season https://keegantheatre.com/onstage/
Kennedy Center (DC) - https://www.kennedy-center.org/whats-on/season-announcement/theate
Theater J (DC) - not out yet but One Jewish Boy playing now
National Theatre (DC) - https://www.broadwayatthenational.com/season-tickets/
Olney Theatre (Olney, MD) - http://www.olneytheatre.org/whats-playing/become-membeclassic-membership
Roundhouse Theatre (Bethesda, MD) - https://www.roundhousetheatre.org/Subscribe2023
Shakespeare Theatre Company (DC)- https://www.shakespearetheatre.org/events/23-24-season-subscriptions/
Signature Theatre (Arlington, VA) - https://www.sigtheatre.org/events/
Studio Theatre (DC) - https://www.studiotheatre.org/plays/play-detail/2023-2024
Synetic Theatre (Arlington, VA) - https://synetictheater.org/seasons/2023-2024/
Woolly Mammoth (DC) - https://www.woollymammoth.net/current-season/2023-2024-season
submitted by blackknight1 to washingtondc [link] [comments]
Many of the theaters listed have discounts such as rush tickets, student tickets or pay what you can (usually the first week).
Lastly check out https://theatrewashington.org for all shows currently playing
Arena Stage (DC) - https://www.arenastage.org/tickets/2023-24-season/
Folger Theatre (DC) - https://events.folger.edu/packages/fixed/1315
Ford’s Theatre (DC) - https://fords.org/whats-happening/2023-2024-season
Keegan Theatre (DC) - not out yet but two shows left this season https://keegantheatre.com/onstage/
Kennedy Center (DC) - https://www.kennedy-center.org/whats-on/season-announcement/theate
Theater J (DC) - not out yet but One Jewish Boy playing now
National Theatre (DC) - https://www.broadwayatthenational.com/season-tickets/
Olney Theatre (Olney, MD) - http://www.olneytheatre.org/whats-playing/become-membeclassic-membership
Roundhouse Theatre (Bethesda, MD) - https://www.roundhousetheatre.org/Subscribe2023
Shakespeare Theatre Company (DC)- https://www.shakespearetheatre.org/events/23-24-season-subscriptions/
Signature Theatre (Arlington, VA) - https://www.sigtheatre.org/events/
Studio Theatre (DC) - https://www.studiotheatre.org/plays/play-detail/2023-2024
Synetic Theatre (Arlington, VA) - https://synetictheater.org/seasons/2023-2024/
Woolly Mammoth (DC) - https://www.woollymammoth.net/current-season/2023-2024-season
2023.06.02 15:01 PritchettRobert506 [HIRING] 25 Jobs in MD Hiring Now!
2023.06.02 11:16 mcarthurlocksmith21 MacArthur Locks & Doors - Commercial Door Installation
https://reddit.com/link/13y7opt/video/4lclmxxunk3b1/player
MacArthur Locks & Doors had a commercial door installation project in Bethesda, MD. The business owner called for a commercial door replacement service as they wanted to replace old doors for their business. We quickly responded to their request for a commercial door Bethesda, MD as the business owner was looking for a commercial door company. We were able to replace the exterior doors.
Call us 24/7 for any commercial door installation services (202) 760-4589
submitted by mcarthurlocksmith21 to u/mcarthurlocksmith21 [link] [comments]
https://reddit.com/link/13y7opt/video/4lclmxxunk3b1/player
MacArthur Locks & Doors had a commercial door installation project in Bethesda, MD. The business owner called for a commercial door replacement service as they wanted to replace old doors for their business. We quickly responded to their request for a commercial door Bethesda, MD as the business owner was looking for a commercial door company. We were able to replace the exterior doors.
Call us 24/7 for any commercial door installation services (202) 760-4589
2023.06.02 11:03 ai_jobs [HIRING] Data Analyst, Medicare Advantage, Remote in Bethesda, MD
![[HIRING] Data Analyst, Medicare Advantage, Remote in Bethesda, MD](https://external-preview.redd.it/sJ2RCEsfy5YHpXQUc5kFDUf1oA7D82cZVPMkbxEdtmM.jpg?width=640&crop=smart&auto=webp&s=125fd8d8355e3e284be90383ef7d42afee3db02d "[HIRING] Data Analyst, Medicare Advantage, Remote in Bethesda, MD") | submitted by ai_jobs to ai_ml_jobs [link] [comments] |
2023.06.01 15:25 PritchettRobert506 [HIRING] 25 Jobs in MD Hiring Now!
2023.06.01 12:15 mcarthurlocksmith21 MacArthur Locks & Doors - Residential Door Repair
https://reddit.com/link/13xdqj2/video/yen1mrdftd3b1/player
MacArthur Locks & Doors had a lock replacement and security lock project in Bethesda, MD. The homeowner called for a locksmith as they wanted to upgrade their locks to new security locks. We quickly responded to their request for a locksmith Bethesda as the homeowner was looking for a residential locksmith. We were able to replace all the exterior locks with new security locks.
Call us 24/7 for any commercial door installation service (202) 760-4589
submitted by mcarthurlocksmith21 to u/mcarthurlocksmith21 [link] [comments]
https://reddit.com/link/13xdqj2/video/yen1mrdftd3b1/player
MacArthur Locks & Doors had a lock replacement and security lock project in Bethesda, MD. The homeowner called for a locksmith as they wanted to upgrade their locks to new security locks. We quickly responded to their request for a locksmith Bethesda as the homeowner was looking for a residential locksmith. We were able to replace all the exterior locks with new security locks.
Call us 24/7 for any commercial door installation service (202) 760-4589
2023.06.01 04:00 hby1091 Maryland erotic massage
Best place in Bethesda md for erotic massage
submitted by hby1091 to EscortClientOnly [link] [comments]
2023.05.31 23:04 zaddee 2x Taqueria El Jalapeno Food Truck (Bethesda, MD / DMV)
 | Meh. Cantelope juice + lemonade, quart container submitted by zaddee to toogoodtogo [link] [comments] |
2023.05.31 15:01 PritchettRobert506 [HIRING] 25 Jobs in MD Hiring Now!
2023.05.29 17:41 jhpratt2 $nwbo-Pakistan
Currently, NWBO's Sawston plant is the only visible global hub for DC VAX L manufacturing and distribution (MHRA MIA approval 3/20/23) . For $400 , FED EX (https://www.fedex.com/en-us/custom-critical.html) ships anywhere globally within the required timeframes.A SAGE (https://journals.sagepub.com/doi/10.1177/20363613231179541) 5/26/23 scientific publication demonstrates intent by Pakistani neurosurgeons to treat and cure their GBM patients. Looks like the DC VAX L JAMA paper and LIAU- Bosch presentations since 10/26/22 have created global awareness that DCVAX L will be is a major global cell based biotech therapy, addressing GBM , and all solid tumors( https://conferences.asco.org/am/industry-expert-theater).
With 50% of LIAU-SPORE-UCLA combo patents living 10 years, DC VAX L has turned SOC's GBM treatment from a terminal (16.5) months disease into a chronic treatable malignancy .
Dr. Greg Zivic:
"This treatment can turn a Glioblastoma into a chronic treatable disease even after recurrence of the tumor . "
https://nwbio.com/northwest-biotherapeutics-and-advent-bioservices-announce-receipt-of-license-for-commercial-manufacturing-at-sawston-u-k-facility/
https://twitter.com/AllenTurner206/status/1636426400382205952
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=171479167
Monday, May 29, 2023 9:13:34 AM
Post# 596739 of 596755 4 Pakistani neurosurgeons endorsing the JAMA Liau dc vax l phase 3 study. Will the RA in Pakistan facilitate their patients' resected GBM tumors and lysate being sent to Sawston , with syringes of dc vax l sent back to Pakistan?
https://jamanetwork.com/journals/jamaoncology/fullarticle/2798847
https://journals.sagepub.com/doi/10.1177/20363613231179541
https://pubmed.ncbi.nlm.nih.gov/36591625/
IMO,BB's consultant is a "legend ", as alleged.Therefore, I recommend reading every on of his posts, word for word.
Bright Boy Brian F Egolf Sr M: Bright Boy
Re: ae kusterer post# 593171
Sunday, May 14, 2023 2:22:21 PM
Post# 593185 of 593185 I am definitely not a biotech expert and what I've learned about Northwest and DCVax-l was shared with me by one of the legends in the biotech world !!! My biggest takeaway is this:
From 2018 forward, it became apparent that DCVax-L was a breakthrough, technological process for the treatment of nGBM and rGBM, but its true potential was only known by a "handful" of experts, and as such, the understanding of the broader market implications was a relative unknown. Early on, several of the comments that I heard from BP were," The GBM market is really not that big!" and " Personalized, Immunotherapy vaccines are not really in our 'Wheelhouse'. We sell compounds/pills!!" On and on! The comments didn't mean that BP wasn't paying attention! Quite the contrary, BP was watching like a hawk as results from Dr. Liau and the UCLA trials began to leak into the medical community suggesting a broader application of DCVax-L on a "stand alone" basis and in combination with CI's for all large tumor cancers ( mentioned in the latest 10Q for future trials), thus dramatically expanding market potentials!!! But the "Big Moment" occurred in late October of last year when the STADIUM LIGHTS turned on, shining bright lights on the latest nGBM/rGBM ,Dr. Liau trial data suggesting 50%to 65% OS for 8 years with emphasis on rGBM !!! That was the point in time when BP and the entire biotech world realized that GBM/rGBM would be treated and managed as a CHRONIC DISEASE!!! with unlimited PROMISE and HOPE for patients and unlimited marketing potential to finance existing vaccine production and the continuing development for improved treatments for all diseases!!!!!
So that's what I learned and that's my story and I'm stickin to it!!!!
Cheers especially to all the Mom's and to everyone !!!
BB
Joseph H.Pratt: https://investorshub.advfn.com/boards/read_msg.aspx?message_id=172010930
Bright Boy Re: None Saturday, March 18, 2023 12:38:55 PM Post# of 596750 Go People, People, People !!!!
The light switch just turned on for me !!! I'm not a doctor or scientist or a STEM concentration "rock star", but if I read something over and over again several times and look carefully at the pictures SOMETIMES, NOT ALL THE TIME, a major mental breakthrough occurs and I believe that I've discovered something very profound!!
In this case, I believe the main message from the slide deck is that DCVax-L, either by itself or in combination with CI's has turned the whole thing around for treating nGBM/rGBM from having to kill the tumor to a "management process" !! It looks like now with this new information, that GBM patients can receive vaccinations as needed with "Zero" side effects and live a long and happy life !!! A comment from a medical expert that DOES KNOW !!!:
Dr. Greg Zivic:
This treatment can turn a Glioblastoma into a chronic treatable disease even after recurrence of the tumor.
So help me out here. Does the above reasoning seem logical based on the slides all of us have just reviewed?? If it does or is, then little Team Northwest has just changed the healthcare landscape forever in the way that we treat disease!!!!!
Am I way off base or are all of onto to something that is fabulous beyond belief???
Cheers,
BB
Bright Boy Re: thermopost# 591947 Tuesday, May 09, 2023 8:41:30 PM Post# of 596749 Go The UK is determined to be the world carrousel for use of immunotherapy vaccines to treat cancers and all forms of disease!!! From my friends in the UK, my use of the word "determined" grossly understates the effort behind the "Grand Plan"!!
So far, the MHRA has not only accepted and approved the MIA application (manufacturing license), but voluntarily offered the expansion to a GLOBAL MANUFACTURING" license allowing for the import of live cells and the export of vaccines to the far corners of the earth!!! People!!! That is huge!!!!! BUT as always 99.99% of the retail investors don't understand the significance of that license or anything else about the process and look to the screen to validate the importance/value of the license, where they are greeted by Citadel and Virtu and the rest of the gang that manipulate the price to new lows, confirming that, in spite of everything they just read from the greatest medical minds in the universe, is a bunch of crap!!!!
Fortunately for the cancer patients and shareholders of Northwest, the MHRA does not include in their decision making process the current SP of NWBO or the opinion of the "gutter filth" that manage those companies or any other companies that participate in the ordered destruction of small biotechs that are engaged in the development of immunotherapy vaccines!! So, it's on to the filing of the MAA (marketing license), the approval and the decisions that will guarantee swift treatment deliveries to patients!!
So Griffin and Cifu and Fuerstein and the rest can lie all they want , but the GREAT UNITED KINGDOM will not be denied the ultimate crown of being the WORLD CENTER for CANCER TREATMENT !!!!!
Cheers,
BB
Bright Boy Re: hoffmann6383post# 578889 Tuesday, March 21, 2023 1:55:12 PM Post# of 596749 Go People, People, People!!! It's your friendly "hillbilly" here with some more great news!! Don't know if I can "one up" my earlier post about the "Dog eating the license", but I'll try. So here we go!!
I don't think everyone realizes how dynamic and important the manufacturing license really is so I'll take a shot at giving you my take on it. First of all, the marketing approval (MAA) and the government subsidy approval(NICE) are pretty much in the bag before the manufacturing team gets the "green light" to proceed. The MAA and NICE teams talk to the MIA team and say," This stuff looks really cool and we wanted to let you know before you run off and do a lot of work on something that we won't approve when you're finished!!" Okay! So that's the first part.
Now for the second part and this is the part that involves a lot of money so read very carefully!!! The MIA license allows for global export of the vaccines and global import of immune cells/tumor resected material. Anyone in the entire world that is diagnosed with GBM can NOW ship their tumor samples to Northwest/Advent/Sawston to have their personal vaccine made and stored, all to be shipped back to the patient/doctor on a prescribed injection schedule. The beauty of this process is that patients everywhere can NOW receive their vaccine on a compassionate care basis. No more waiting!! No more opportunities for the "dark forces" to delay or deny suffering cancer patients their desperately needed treatments !!!
People, as of yesterday, Northwest is now IN BUSINESS !!!! AND that opens the door for institutional investors and an uplist to the New York or Nasdaq exchanges!!!!
All of the above is as good as that first sip of ice cold buttermilk on a hot summer day!!!! AND for those unfortunate shorts and haters it adds a whole new description to the letters FTD and I'll let you guess what that might be!!!
Cheers,
BB
Bright Boy Re: None Tuesday, March 21, 2023 9:05:54 PM Post# of 596749 Go The MIA allows for "International Immune Cell Imports" and "International Vaccine Exports" !!! That is big news and a big, big market and should access every cancer patient in need!!!!
Cheers,
BB
ae kusterer
Re: None
Monday, May 29, 2023 9:13:34 AM
Post# 596739 of 596755 4 Pakistani neurosurgeons endorsing the JAMA Liau dc vax l phase 3 study. Will the RA in Pakistan facilitate their patients' resected GBM tumors and lysate being sent to Sawston , with syringes of dc vax l sent back to Pakistan?
https://jamanetwork.com/journals/jamaoncology/fullarticle/2798847
https://journals.sagepub.com/doi/10.1177/20363613231179541
https://pubmed.ncbi.nlm.nih.gov/36591625/
Abstract Objective: To define the landscape of treatment patterns and current epidemiological data regarding gliomas in Pakistan.
Methods: As part of the Pakistan Brain Tumour Epidemiology Study (PBTES), data were collected from 32 neurosurgical centres across the country. Our retrospective study looked at patients who underwent surgical procedures for gliomas in 2019 in neurosurgical centres. The data was collated and analysed using STATA version 15.
Results: A total of 781 patients with gliomas were identified 479(61.8%) in public sector hospitals, 302(39.1%) in the private sector). The most common histopathological subtypes were glioblastoma 262 (33.5%), followed by astrocytoma 147(18.8%) and oligodendroglioma 93(11.9%). Gender distribution was skewed towards men 508(65%). Private institution hospitals performed surgical biopsies as the first surgical procedure 75(23%) more often than public hospitals 38(9%). Chemotherapy was given to 115(29.8%) patients, and there was no data regarding 467(53%) of patients. Similarly, only 202(43.9%) patients received radiation therapy, and there was no data for 469(60%) of patients. For high-grade gliomas specifically, only 95(31.8%) patients with HGG have a record of receiving radiation therapy, and only 57(18.9%) had a record of being started on chemotherapy.
DCvax: A promising advancement in oncology for the treatment of glioblastoma Areeba Fareed https://orcid.org/0000-0001-5906-9852 [email protected], Samia Rohail https://orcid.org/0000-0003-1488-0080, […], and Abdul Moiz Khan https://orcid.org/0000-0001-9796-8867+1View all authors and affiliations All Articles https://doi.org/10.1177/20363613231179541
Contents Declaration of conflicting interests Funding ORCID iDs Footnotes References PDF / ePub More Dear Editor, Glioblastoma is a malignant neoplasm of the central nervous system that arises from glial cells, primarily astrocyctes and is characterized by poorly differentiated, fusiform, round or pleomorphic astrocyctic cells with marked nuclear atypical and brisk mitotic activity.1 Despite advances in early diagnosis and comprehensive treatments, there is nearly 100% recurrence rate and dismal patient survival.2 According to researchers, more than 13,000 Americans are diagnosed with Glioblastoma annually, causing significant morbidity and mortality. There has been no cure for Glioblastoma so far.3 Treatment options often include surgical removal of the tumor followed by concomitant radiation and adjuvant temozolomide TMZ chemotherapy which has been the standard of care for glioblastoma since decades, but exposure to high doses of ionizing radiation is a well-known exogenous risk factor for glioblastoma. The inability to cross the BBB is the major obstacle in achieving remission after surgical resection followed by chemotherapy and radiation.4 As a result, glioblastoma typically recurs within six to 8 months and the survival rate is generally less than 5%.2 Despite the development of novel, complex, multidisciplinary, and targeted therapies the outcome for patients remains almost universally lethal.5 Therefore, the need for effective treatment is undeniable. For this reason, it has been a priority area in cancer research. Recently, US biotech company Northwest Biotherapeutics has developed a brain cancer vaccine, called DCVax, which is designed to help patients' immune system to target their tumors that may prolong their life by months or, in some cases, years.5 Thus, opening a door for the development of innovative therapy for targeting glioblastoma. The vaccine is created for each patient individually by isolating dendritic cells, from their blood which is then primed with biomarkers from a sample of the patient’s tumor.6 Dendritic cells present tumor antigens to the immune system, prime T cells, and mobilize antitumor responses.6 To evaluate the safety of the vaccine and its impact on survival time in patients with Glioblastoma, a phase 3 randomized control trial was conducted.7 In this trial, 348 patients newly diagnosed with Glioblastoma were tested at King’s College Hospital and other centers around the world for 8 years.7 Patients had surgery to remove their tumors as much as possible, followed by radiation and chemotherapy as the standard treatment for Glioblastoma.7 Among these patients, two out of three were treated with the vaccine, DCVax-L, with the remaining one-third receiving a placebo.7 The astonishing result of the trial has shown that newly diagnosed patients who received the vaccine survived for 19.3 months compared to 16.5 months for those who received a placebo.8 Overall 13% of all trial participants treated with DCVax lived more than 5 years after diagnosis compared with 5.7% in the comparison group who did so.8 Moreover, this is the first time in 17 years that such a significant result has been achieved in a Phase 3 trial of a systemic treatment for newly diagnosed Glioblastoma, and it’s the first treatment in 27 years for patients with GBM recurrence.9 Thus, this development represents a major step forward in our efforts to combat this devastating disease. Based on the findings of the trials evaluating the drug’s efficacy, it has the potential to improve the quality of life for patients, especially for the elderly and those unable to have surgery. A global clinical trial has concluded that the DCVax is the world’s first vaccine to treat deadly cancerous brain tumors that could help patients to live for years.9 This breakthrough could benefit 2500 people a year in the UK being diagnosed with Glioblastoma.9 It has also been shown that this therapy can be used to treat cancers other than Glioblastoma.9 However, due to high recurrence rate and lethal outcomes, the treatment of gliblastoma has seen significant transformation, switching from an aggressive surgical strategy to a more cautious one. The endorsement of the vaccine is a commendable achievement, and it demonstrates the unwavering commitment of researchers and healthcare professionals to discovering effective treatments for such lethal disease. Furthermore, vaccine may enhance the quality of life of a patient and provides a new hope for patients and their families Thus, it is crucial that we continue to support research into Glioblastoma and the development of novel treatments so that we can envision a future where this disease is eradicated. Declaration of conflicting interests The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Funding The author(s) received no financial support for the research, authorship, and/or publication of this article. ORCID iDs Areeba Fareed https://orcid.org/0000-0001-5906-9852 Samia Rohail https://orcid.org/0000-0003-1488-0080 Alishba Adnan https://orcid.org/0000-0003-1238-6687 Abdul Moiz Khan https://orcid.org/0000-0001-9796-8867 Footnotes Author’s noteNot commissioned, externally peer reviewed. ContributorshipAreeba Fareed and Samia Rohail wrote the draft. Alishba Adnan and Abdul Moiz Khan proofread it. All authors reviewed and edited the manuscript and approved the final version of the manuscript. Data availabilityNo new dataset generated. References 1. Aans.org. Available from: https://www.aans.org/Patients/Neurosurgical-Conditions-and-Treatments/Glioblastoma-Multiforme%5d (cited 9 April 2023). GO TO REFERENCE Google Scholar 2. Liau LM, Ashkan K, Brem S, et al. Association of autologous tumor lysate-loaded dendritic cell vaccination with extension of survival among patients with newly diagnosed and recurrent glioblastoma: a phase 3 prospective externally controlled cohort trial: a phase 3 prospective externally controlled cohort trial. JAMA Oncol 2023; 9(1): 112–121. Available from: https://jamanetwork.com/journals/jamaoncology/fullarticle/2798847 (cited 9 April 2023).
PubMed Google Scholar 3. Pelc C. Experimental cancer vaccine both treats and prevents brain cancer in mice [Internet]. East Sussex, UK: Medical News Today, 2023. Available from: https://www.medicalnewstoday.com/articles/experimental-cancer-vaccine-both-treats-and-prevents-brain-cancer-in-mice (cited 9 April 2023). GO TO REFERENCE Google Scholar 4. Rong L, Li N, Zhang Z. Emerging therapies for glioblastoma: current state and future directions. J Exp Clin Cancer Res 2022; 41(1): 142. (cited 9 April 2023). GO TO REFERENCE Crossref PubMed Google Scholar 5. Aldape K, Brindle KM, Chesler L, et al. Challenges to curing primary brain tumours. Nat Rev Clin Oncol 2019; 16(8): 509–520. Available from: https://www.nature.com/articles/s41571-019-0177-5 (cited 9 April 2023).
Crossref PubMed Google Scholar 6. Technology Networks. Brain cancer vaccine shown to extend patient survival [Internet]. Sudbury, UK: Technology Networks, 2022. Available from: https://www.technologynetworks.com/vaccines/news/brain-cancer-vaccine-shown-to-extend-patient-survival-367721 (cited 9 April 2023).
Google Scholar 7. Clinicaltrials.gov. Study of a drug [DCVax®-L] to treat newly diagnosed GBM brain cancer - full text view - Clinicaltrials.gov [internet]. Bethesda, MD: Clinicaltrials.gov, 2023. Available from: https://clinicaltrials.gov/ct2/show/NCT00045968 (cited 9 April 2023).
Google Scholar 8. Campbell D. Vaccine shown to prolong life of patients with aggressive brain cancer. London, UK: The guardian [Internet], 2022. Available from: https://www.theguardian.com/science/2022/nov/17/vaccine-shown-to-prolong-life-patients-aggressive-brain-cancer-trial-glioblastoma (cited 9 April 2023).
Google Scholar 9. Delgado-Martín B, Medina MÁ. Advances in the knowledge of the molecular biology of glioblastoma and its impact in patient diagnosis, stratification, and treatment. Adv Sci 2020; 7(9): 1902971.
Crossref Google Scholar📷 0 Share Reply/Post Keep Last Read More Next 10 Prev NextNWBONorthwest Biotherapeutics Inc (QB)0.615 0.011 (1.82%)Volume:1,013,957Day Range:0.6011 - 0.62Bid:0.61Ask:0.615Last Trade Time:3:59:10 PM EDTTotal Trades:378
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Start posting your company's newsOnly $200 per official company press release!
submitted by jhpratt2 to NWBO [link] [comments]
With 50% of LIAU-SPORE-UCLA combo patents living 10 years, DC VAX L has turned SOC's GBM treatment from a terminal (16.5) months disease into a chronic treatable malignancy .
Dr. Greg Zivic:
"This treatment can turn a Glioblastoma into a chronic treatable disease even after recurrence of the tumor . "
https://nwbio.com/northwest-biotherapeutics-and-advent-bioservices-announce-receipt-of-license-for-commercial-manufacturing-at-sawston-u-k-facility/
https://twitter.com/AllenTurner206/status/1636426400382205952
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=171479167
Monday, May 29, 2023 9:13:34 AM
Post# 596739 of 596755 4 Pakistani neurosurgeons endorsing the JAMA Liau dc vax l phase 3 study. Will the RA in Pakistan facilitate their patients' resected GBM tumors and lysate being sent to Sawston , with syringes of dc vax l sent back to Pakistan?
https://jamanetwork.com/journals/jamaoncology/fullarticle/2798847
https://journals.sagepub.com/doi/10.1177/20363613231179541
https://pubmed.ncbi.nlm.nih.gov/36591625/
IMO,BB's consultant is a "legend ", as alleged.Therefore, I recommend reading every on of his posts, word for word.
Bright Boy Brian F Egolf Sr M: Bright Boy
Re: ae kusterer post# 593171
Sunday, May 14, 2023 2:22:21 PM
Post# 593185 of 593185 I am definitely not a biotech expert and what I've learned about Northwest and DCVax-l was shared with me by one of the legends in the biotech world !!! My biggest takeaway is this:
From 2018 forward, it became apparent that DCVax-L was a breakthrough, technological process for the treatment of nGBM and rGBM, but its true potential was only known by a "handful" of experts, and as such, the understanding of the broader market implications was a relative unknown. Early on, several of the comments that I heard from BP were," The GBM market is really not that big!" and " Personalized, Immunotherapy vaccines are not really in our 'Wheelhouse'. We sell compounds/pills!!" On and on! The comments didn't mean that BP wasn't paying attention! Quite the contrary, BP was watching like a hawk as results from Dr. Liau and the UCLA trials began to leak into the medical community suggesting a broader application of DCVax-L on a "stand alone" basis and in combination with CI's for all large tumor cancers ( mentioned in the latest 10Q for future trials), thus dramatically expanding market potentials!!! But the "Big Moment" occurred in late October of last year when the STADIUM LIGHTS turned on, shining bright lights on the latest nGBM/rGBM ,Dr. Liau trial data suggesting 50%to 65% OS for 8 years with emphasis on rGBM !!! That was the point in time when BP and the entire biotech world realized that GBM/rGBM would be treated and managed as a CHRONIC DISEASE!!! with unlimited PROMISE and HOPE for patients and unlimited marketing potential to finance existing vaccine production and the continuing development for improved treatments for all diseases!!!!!
So that's what I learned and that's my story and I'm stickin to it!!!!
Cheers especially to all the Mom's and to everyone !!!
BB
Joseph H.Pratt: https://investorshub.advfn.com/boards/read_msg.aspx?message_id=172010930
Bright Boy Re: None Saturday, March 18, 2023 12:38:55 PM Post# of 596750 Go People, People, People !!!!
The light switch just turned on for me !!! I'm not a doctor or scientist or a STEM concentration "rock star", but if I read something over and over again several times and look carefully at the pictures SOMETIMES, NOT ALL THE TIME, a major mental breakthrough occurs and I believe that I've discovered something very profound!!
In this case, I believe the main message from the slide deck is that DCVax-L, either by itself or in combination with CI's has turned the whole thing around for treating nGBM/rGBM from having to kill the tumor to a "management process" !! It looks like now with this new information, that GBM patients can receive vaccinations as needed with "Zero" side effects and live a long and happy life !!! A comment from a medical expert that DOES KNOW !!!:
Dr. Greg Zivic:
This treatment can turn a Glioblastoma into a chronic treatable disease even after recurrence of the tumor.
So help me out here. Does the above reasoning seem logical based on the slides all of us have just reviewed?? If it does or is, then little Team Northwest has just changed the healthcare landscape forever in the way that we treat disease!!!!!
Am I way off base or are all of onto to something that is fabulous beyond belief???
Cheers,
BB
Bright Boy Re: thermopost# 591947 Tuesday, May 09, 2023 8:41:30 PM Post# of 596749 Go The UK is determined to be the world carrousel for use of immunotherapy vaccines to treat cancers and all forms of disease!!! From my friends in the UK, my use of the word "determined" grossly understates the effort behind the "Grand Plan"!!
So far, the MHRA has not only accepted and approved the MIA application (manufacturing license), but voluntarily offered the expansion to a GLOBAL MANUFACTURING" license allowing for the import of live cells and the export of vaccines to the far corners of the earth!!! People!!! That is huge!!!!! BUT as always 99.99% of the retail investors don't understand the significance of that license or anything else about the process and look to the screen to validate the importance/value of the license, where they are greeted by Citadel and Virtu and the rest of the gang that manipulate the price to new lows, confirming that, in spite of everything they just read from the greatest medical minds in the universe, is a bunch of crap!!!!
Fortunately for the cancer patients and shareholders of Northwest, the MHRA does not include in their decision making process the current SP of NWBO or the opinion of the "gutter filth" that manage those companies or any other companies that participate in the ordered destruction of small biotechs that are engaged in the development of immunotherapy vaccines!! So, it's on to the filing of the MAA (marketing license), the approval and the decisions that will guarantee swift treatment deliveries to patients!!
So Griffin and Cifu and Fuerstein and the rest can lie all they want , but the GREAT UNITED KINGDOM will not be denied the ultimate crown of being the WORLD CENTER for CANCER TREATMENT !!!!!
Cheers,
BB
Bright Boy Re: hoffmann6383post# 578889 Tuesday, March 21, 2023 1:55:12 PM Post# of 596749 Go People, People, People!!! It's your friendly "hillbilly" here with some more great news!! Don't know if I can "one up" my earlier post about the "Dog eating the license", but I'll try. So here we go!!
I don't think everyone realizes how dynamic and important the manufacturing license really is so I'll take a shot at giving you my take on it. First of all, the marketing approval (MAA) and the government subsidy approval(NICE) are pretty much in the bag before the manufacturing team gets the "green light" to proceed. The MAA and NICE teams talk to the MIA team and say," This stuff looks really cool and we wanted to let you know before you run off and do a lot of work on something that we won't approve when you're finished!!" Okay! So that's the first part.
Now for the second part and this is the part that involves a lot of money so read very carefully!!! The MIA license allows for global export of the vaccines and global import of immune cells/tumor resected material. Anyone in the entire world that is diagnosed with GBM can NOW ship their tumor samples to Northwest/Advent/Sawston to have their personal vaccine made and stored, all to be shipped back to the patient/doctor on a prescribed injection schedule. The beauty of this process is that patients everywhere can NOW receive their vaccine on a compassionate care basis. No more waiting!! No more opportunities for the "dark forces" to delay or deny suffering cancer patients their desperately needed treatments !!!
People, as of yesterday, Northwest is now IN BUSINESS !!!! AND that opens the door for institutional investors and an uplist to the New York or Nasdaq exchanges!!!!
All of the above is as good as that first sip of ice cold buttermilk on a hot summer day!!!! AND for those unfortunate shorts and haters it adds a whole new description to the letters FTD and I'll let you guess what that might be!!!
Cheers,
BB
Bright Boy Re: None Tuesday, March 21, 2023 9:05:54 PM Post# of 596749 Go The MIA allows for "International Immune Cell Imports" and "International Vaccine Exports" !!! That is big news and a big, big market and should access every cancer patient in need!!!!
Cheers,
BB
ae kusterer
Re: None
Monday, May 29, 2023 9:13:34 AM
Post# 596739 of 596755 4 Pakistani neurosurgeons endorsing the JAMA Liau dc vax l phase 3 study. Will the RA in Pakistan facilitate their patients' resected GBM tumors and lysate being sent to Sawston , with syringes of dc vax l sent back to Pakistan?
https://jamanetwork.com/journals/jamaoncology/fullarticle/2798847
https://journals.sagepub.com/doi/10.1177/20363613231179541
https://pubmed.ncbi.nlm.nih.gov/36591625/
Abstract Objective: To define the landscape of treatment patterns and current epidemiological data regarding gliomas in Pakistan.
Methods: As part of the Pakistan Brain Tumour Epidemiology Study (PBTES), data were collected from 32 neurosurgical centres across the country. Our retrospective study looked at patients who underwent surgical procedures for gliomas in 2019 in neurosurgical centres. The data was collated and analysed using STATA version 15.
Results: A total of 781 patients with gliomas were identified 479(61.8%) in public sector hospitals, 302(39.1%) in the private sector). The most common histopathological subtypes were glioblastoma 262 (33.5%), followed by astrocytoma 147(18.8%) and oligodendroglioma 93(11.9%). Gender distribution was skewed towards men 508(65%). Private institution hospitals performed surgical biopsies as the first surgical procedure 75(23%) more often than public hospitals 38(9%). Chemotherapy was given to 115(29.8%) patients, and there was no data regarding 467(53%) of patients. Similarly, only 202(43.9%) patients received radiation therapy, and there was no data for 469(60%) of patients. For high-grade gliomas specifically, only 95(31.8%) patients with HGG have a record of receiving radiation therapy, and only 57(18.9%) had a record of being started on chemotherapy.
DCvax: A promising advancement in oncology for the treatment of glioblastoma Areeba Fareed https://orcid.org/0000-0001-5906-9852 [email protected], Samia Rohail https://orcid.org/0000-0003-1488-0080, […], and Abdul Moiz Khan https://orcid.org/0000-0001-9796-8867+1View all authors and affiliations All Articles https://doi.org/10.1177/20363613231179541
Contents Declaration of conflicting interests Funding ORCID iDs Footnotes References PDF / ePub More Dear Editor, Glioblastoma is a malignant neoplasm of the central nervous system that arises from glial cells, primarily astrocyctes and is characterized by poorly differentiated, fusiform, round or pleomorphic astrocyctic cells with marked nuclear atypical and brisk mitotic activity.1 Despite advances in early diagnosis and comprehensive treatments, there is nearly 100% recurrence rate and dismal patient survival.2 According to researchers, more than 13,000 Americans are diagnosed with Glioblastoma annually, causing significant morbidity and mortality. There has been no cure for Glioblastoma so far.3 Treatment options often include surgical removal of the tumor followed by concomitant radiation and adjuvant temozolomide TMZ chemotherapy which has been the standard of care for glioblastoma since decades, but exposure to high doses of ionizing radiation is a well-known exogenous risk factor for glioblastoma. The inability to cross the BBB is the major obstacle in achieving remission after surgical resection followed by chemotherapy and radiation.4 As a result, glioblastoma typically recurs within six to 8 months and the survival rate is generally less than 5%.2 Despite the development of novel, complex, multidisciplinary, and targeted therapies the outcome for patients remains almost universally lethal.5 Therefore, the need for effective treatment is undeniable. For this reason, it has been a priority area in cancer research. Recently, US biotech company Northwest Biotherapeutics has developed a brain cancer vaccine, called DCVax, which is designed to help patients' immune system to target their tumors that may prolong their life by months or, in some cases, years.5 Thus, opening a door for the development of innovative therapy for targeting glioblastoma. The vaccine is created for each patient individually by isolating dendritic cells, from their blood which is then primed with biomarkers from a sample of the patient’s tumor.6 Dendritic cells present tumor antigens to the immune system, prime T cells, and mobilize antitumor responses.6 To evaluate the safety of the vaccine and its impact on survival time in patients with Glioblastoma, a phase 3 randomized control trial was conducted.7 In this trial, 348 patients newly diagnosed with Glioblastoma were tested at King’s College Hospital and other centers around the world for 8 years.7 Patients had surgery to remove their tumors as much as possible, followed by radiation and chemotherapy as the standard treatment for Glioblastoma.7 Among these patients, two out of three were treated with the vaccine, DCVax-L, with the remaining one-third receiving a placebo.7 The astonishing result of the trial has shown that newly diagnosed patients who received the vaccine survived for 19.3 months compared to 16.5 months for those who received a placebo.8 Overall 13% of all trial participants treated with DCVax lived more than 5 years after diagnosis compared with 5.7% in the comparison group who did so.8 Moreover, this is the first time in 17 years that such a significant result has been achieved in a Phase 3 trial of a systemic treatment for newly diagnosed Glioblastoma, and it’s the first treatment in 27 years for patients with GBM recurrence.9 Thus, this development represents a major step forward in our efforts to combat this devastating disease. Based on the findings of the trials evaluating the drug’s efficacy, it has the potential to improve the quality of life for patients, especially for the elderly and those unable to have surgery. A global clinical trial has concluded that the DCVax is the world’s first vaccine to treat deadly cancerous brain tumors that could help patients to live for years.9 This breakthrough could benefit 2500 people a year in the UK being diagnosed with Glioblastoma.9 It has also been shown that this therapy can be used to treat cancers other than Glioblastoma.9 However, due to high recurrence rate and lethal outcomes, the treatment of gliblastoma has seen significant transformation, switching from an aggressive surgical strategy to a more cautious one. The endorsement of the vaccine is a commendable achievement, and it demonstrates the unwavering commitment of researchers and healthcare professionals to discovering effective treatments for such lethal disease. Furthermore, vaccine may enhance the quality of life of a patient and provides a new hope for patients and their families Thus, it is crucial that we continue to support research into Glioblastoma and the development of novel treatments so that we can envision a future where this disease is eradicated. Declaration of conflicting interests The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Funding The author(s) received no financial support for the research, authorship, and/or publication of this article. ORCID iDs Areeba Fareed https://orcid.org/0000-0001-5906-9852 Samia Rohail https://orcid.org/0000-0003-1488-0080 Alishba Adnan https://orcid.org/0000-0003-1238-6687 Abdul Moiz Khan https://orcid.org/0000-0001-9796-8867 Footnotes Author’s noteNot commissioned, externally peer reviewed. ContributorshipAreeba Fareed and Samia Rohail wrote the draft. Alishba Adnan and Abdul Moiz Khan proofread it. All authors reviewed and edited the manuscript and approved the final version of the manuscript. Data availabilityNo new dataset generated. References 1. Aans.org. Available from: https://www.aans.org/Patients/Neurosurgical-Conditions-and-Treatments/Glioblastoma-Multiforme%5d (cited 9 April 2023). GO TO REFERENCE Google Scholar 2. Liau LM, Ashkan K, Brem S, et al. Association of autologous tumor lysate-loaded dendritic cell vaccination with extension of survival among patients with newly diagnosed and recurrent glioblastoma: a phase 3 prospective externally controlled cohort trial: a phase 3 prospective externally controlled cohort trial. JAMA Oncol 2023; 9(1): 112–121. Available from: https://jamanetwork.com/journals/jamaoncology/fullarticle/2798847 (cited 9 April 2023).
PubMed Google Scholar 3. Pelc C. Experimental cancer vaccine both treats and prevents brain cancer in mice [Internet]. East Sussex, UK: Medical News Today, 2023. Available from: https://www.medicalnewstoday.com/articles/experimental-cancer-vaccine-both-treats-and-prevents-brain-cancer-in-mice (cited 9 April 2023). GO TO REFERENCE Google Scholar 4. Rong L, Li N, Zhang Z. Emerging therapies for glioblastoma: current state and future directions. J Exp Clin Cancer Res 2022; 41(1): 142. (cited 9 April 2023). GO TO REFERENCE Crossref PubMed Google Scholar 5. Aldape K, Brindle KM, Chesler L, et al. Challenges to curing primary brain tumours. Nat Rev Clin Oncol 2019; 16(8): 509–520. Available from: https://www.nature.com/articles/s41571-019-0177-5 (cited 9 April 2023).
Crossref PubMed Google Scholar 6. Technology Networks. Brain cancer vaccine shown to extend patient survival [Internet]. Sudbury, UK: Technology Networks, 2022. Available from: https://www.technologynetworks.com/vaccines/news/brain-cancer-vaccine-shown-to-extend-patient-survival-367721 (cited 9 April 2023).
Google Scholar 7. Clinicaltrials.gov. Study of a drug [DCVax®-L] to treat newly diagnosed GBM brain cancer - full text view - Clinicaltrials.gov [internet]. Bethesda, MD: Clinicaltrials.gov, 2023. Available from: https://clinicaltrials.gov/ct2/show/NCT00045968 (cited 9 April 2023).
Google Scholar 8. Campbell D. Vaccine shown to prolong life of patients with aggressive brain cancer. London, UK: The guardian [Internet], 2022. Available from: https://www.theguardian.com/science/2022/nov/17/vaccine-shown-to-prolong-life-patients-aggressive-brain-cancer-trial-glioblastoma (cited 9 April 2023).
Google Scholar 9. Delgado-Martín B, Medina MÁ. Advances in the knowledge of the molecular biology of glioblastoma and its impact in patient diagnosis, stratification, and treatment. Adv Sci 2020; 7(9): 1902971.
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2023.05.27 02:17 jimmyjz2000 Last time I saw an aerodactyl was 2016 so this was pretty thrilling
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2023.05.26 18:00 LabB0T Weekly r/homelabsales Summary - 2023-05-26
The last weeks [For Sale] posts in homelabsales
Posts that have not met the rules of HLS or have completed are not shown.
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CANADA
ON
QC
IL
MN
MO
SD
TX
TX-ATX
WI
FL
KY
LI-NY
MD
NH
PA
TN
VA
NV
UT
WA
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CAN-ANY-
CANADA
ON
QC
EUNL
UK-ANY-
- USW-enterprise-48-poe
- UK - Seagate Exos 8TB SATA (x6)
- NETGEAR Prosafe Plus JGS524E 24 port Gigabit Managed Switch
US-C-ANY-
- Custom Server - Intel Xeon W-1270, Gigabyte W480M, 32GB ECC, RX 6750XT, Define R5
- - Desktop, Laptop, Synology, UBNT Unifi USG (and USG Pro), and EdgeRouter, Netgear Switch
- Dell R540 (16c, 128gb, no drives/caddies)
- Ubiquiti USW-Pro-24-PoE
- 2X Dell Force10 S4810-AC and 2X Dell PowerConnect 5424
IL
- 4x 16GB 2400mhz ECC RAM Modules
- Unifi UAP-AC-PRO 3x and USG and Cloud Key Gen1
- Synology DS3018xs
- HP ProLiant DL360p Gen8 $350
- Raspberry Pi 4 Model B 4GB w/ POE Hat, Mikrotik LtAP LTE6 Rugged Router Kit, Netgear LM1200
- Homelab cleanout - switches, servers, (old) HDDs, etc
- NVMe M.2 SSD (Samsung or XPG) and MSI PCIe Expansion Card
MN
MO
- Various Dell Server Hardware & Misc PC parts
- HBAs & GTX 1050 Ti
- Used Unifi USG Pro w/ Noctua Fans, New in Box Zigbee Devices & Yubikeys
SD
TX
- Tripp Lite Rackmount Cooling Unit 7000BTU, 8U, 120V - Local Only (77471)
- 1 x U6 Mesh & 4 x Enterprise 8 PoE USW-Enterprise-8-PoE (120W)
- Dell PowerConnect 8024 10Gb - CyberPower OR1500LCDRTXL2U
- Brocade ICX 6610-24P, Dell R720 w/ Rails, 960GB WD SN600
- Fast & Quiet PFsense/OPNsense $175
- Homelab Clear Out - AMD Epyc CPU/Mobo/Cooler Combo, x470d4u, and more!
- USG-Pro-4, UCK-Gen2-Plus, UISP-LTE, RAID Cards, Razer Core X
TX-ATX
- Mac Pro tower 2009, dual Xeon, 64g ram
- 4u JBOD case, LSI 8211, SAS expander card, just add drives. $400
WI
- (LOCAL PICKUP) Custom built 4U server
- Unifi USW Pro 48 Port Switch
- Custom 8 Bay NAS
- HP T730 Thin client
US-E-ANY-
- Terra-Master NAS, Samsung LCDs, Microsoft Surface Pro 5, Thunderbolt 3 Docks, Ubiquiti Switches, Logitech G213 Gaming Keyboard, other misc stuff
- HPE Proliant DL380 Gen9
- Lenovo Tiny M920q and HP Mini Desktop Prodesk 400 G5
- 4x quadro 2000, 1x quadro k2200, 1x quadro m4000, 4x quadro k42000
FL
- Dell PowerEdge R210 ii
- 32GB Sandisk Ultra Class 10 Micro SD Card
- G3 instant, UAP-AC-IW
- Optiplex's, NAS's, and thunderbolt 3 docks
- A few new Western Digital enterprise drives
KY
LI-NY
MD
- [Bethesda] Homelab spring cleaning (Local Pickup Only)
- Intel 2U 112-Thread 2x Xeon R2208WFTZS Wolf Pass Servers [$1600]
NH
- HP DL 380 GEN 9 G9 Servers- 256GB DDR4 ECC REG, DUAL XEON! WILL SHIP!
- On SALE 1 Dented DDR4 SERVER + 1 Cisco C220 M4 with no problems !
- Matched Pairs of Xeon 2683 V4, 2680 V4, 2690 V3 Great BUDGET LGA2011-3 Xeons!
- High Spec HP DL360 G9 W/ ERROR MESSAGE! Cheap! Dual 3.2Ghz BASE V4 CPUS! HPE Smart Memory!
- GREAT RAM FOR DELL R720, R620! Under 44Cents/GB! Hynix 32GB DDR3 ECC Registered 1600Mhz PC3L-12800L LR DIMM Memory RAM Modules -- FREE SHIPPING!
- HP/ Samsung PM1725A 1.6TB PCi-E NVME SDDs Genuine HP Part!
- Cisco C3164Q-40GE 64 Port 40GB/s QSFP+ Network Switches---200$ each!!!--
- Desktop Ram for sale
- Mikrotik RB3011
- Raspberry Pi 3 B
- Ram for sale
- 8TB SAS HDDs, DDR3 Server RAM
- Synology DS1817+, 10Gb NIC.
- HP ZBook 17 G6
- R740 16bay 3x5120 128G H330HBA
- Intel DQ77KB ITX motherboard, Intel i5-3570K CPU, Kingston SUV500MS 480GB SSD, 8GB Kingston KVR16S11 RAM, Goodisory A01 mini ITX HTPC case - $200
- ASRock Intel Arc A380 for 5700XT, 2070 etc
- Phantom Gaming X399, ThreadRipper 2950x, 3x i5-6500T, 12U rack
PA
- SuperMicro X11SCA-F IPMI Motherboard, Xeon E-2186G, i3-9100E, 64 GB DDR4-2666 ECC Memory, Corsair Water Cooler -- PRICE REDUCED US-E
- Juniper EX3200-24T 24-Port Gigabit (8-Ports PoE) Switch w/ Rails
- 4x 32GB Corsair DDR4 Noctua NH-U9S ASUS Prime Z590-A GTX 1660 Ti
- SuperMicro X11SCA-F IPMI Motherboard, Xeon E-2186G, i3-9100E, 64 GB DDR4-2666 ECC Memory, Corsair Water Cooler -- PRICE REDUCED
- APC SMX120RMBP2U External Battery Pack
- APC metered PDU, Leviton 48 port patch panel
- Upgraded Synology RS3617xs w/ RX1217, 8x 6TB WD RED, Quad NVMe m.2 to PCIe x16 bifurcation card
TN
VA
- PCIe riser kit, PCIe slot/place, Apple power extension cord
- DDR3 ECC Memory 16GB 8GB 4GB Modules (Samsung, Micron, SK Hynix, and More!)
- Intel CPU
- Verticual GPU/PCIe riser + mounting kit, various Apple things, eufy security camera, and bunch of free stuff
- Dell Precision T5610 2x E5-2690, 64GB RAM
US-W-ANY-
- Apple Mac Mini Late 2018
- Seattle Area - Conbee II Zigbee USB gateway - $15
- Supermicro SuperServer 5018R-M. E5-2650v3, 64GB RAM
- Synology DS1815+, 4x 10TB HDDs, and Ubiquiti Unifi AC Lite
- Dell Optiplex 3080 Micro / NUC8I5BEK1 (AK/HII allowed)
- Unifi US-24-G1 (non-POE) switch
- Raspberry Pi 4 (2GB), HyperPixel 4" Pi Display (Non-touch)
- 3x4TB Ironwolf Pro, 1x4TB Ironwolf, 2x2TB Barracuda, 2x8GB DDR4 2133P SODIMM Memory, 256GB Samsung NVME
- 15U Knock-Down Server Rack Cabinet with Casters - Local Cash
- CLEANOUT!! 4tb HDDs, DDR3/DDR4 ECC and SODIMM 1/2/4/8/16gb sticks, Router, PSUs, 100g cables, HBAs, freebies
- 2 raspberry pi 4’s(2gb)
- StarTech.com 19" 18U Server Rack Cabinet -- RK1833BKM
- USG-PRO-4 // Ubiquiti Security Gateway Pro 4
- RadeonPro WX7100, SSDs, 32GB DDR4 ECC Modules
- Pair - E5 2650 v4
- Intel E5-2630Lv4 CPU
- Dell R710 Dual E5530, 4 x 8gb ram, 6 LFF with 1 300gb SAS
- DDR3 DDR4 RAM / 2011 CPU / SATA DOM
- Ubiquiti UniFi Dream machine
- Dell R330 LFF or SFF. Free Shipping.
NV
UT
WA
- Google Coral USB, Unifi, and smart home gear
- Supermicro 5018D-FN4T 10GbE Front I/O Server, MikroTik 12-Port 10GbE CRS312-4C+8XG-RM Switch, 2x Intel X550-T1 NICs
- 2x Dell R330 8Bay SFF
- Samsung 30.72TB SSD (x3)
2023.05.25 23:15 Expensive-Bobcat2858 [FREE][US-MD][Bethesda] Homelab spring cleaning, free stuff (Local Pickup Only)
After a couple moves, upgrades, and consolidation, I have a lot of gear looking for new homes. Local pickup only, Bethesda, MD 20816. Questions welcome.
https://imgur.com/a/kZbUv1d
QLE2462, various vendors - Free: Low Profile bracket: 12 Full Height bracket: 2 Unused for a couple years, were working
QLE2464: 12 - Free Unused for a couple years, were working
2x dell r710, cpu, no memory, no ipmi Free never used, unknown
Dell MD3220i with expander pci card, no disks - Free never used, unknown
2x 2u 400w SeaSonic power supply - Free Unused for a couple years, were working
SuperMicro X9SCM-F w/ cpu and memory - Free Unused for a couple years, was working
2x dgs-1016d - Free2x dgs-1024d - Free unused for a few years, was working
2x DLA3000RM2U ups no battery, no mgmt card, includes rails - Free never used, one has bent mounting ear, unknown 30/50A L5-30P plug
submitted by Expensive-Bobcat2858 to homelabsales [link] [comments]
https://imgur.com/a/kZbUv1d
Fiber Channel:
Brocade BR-5000 - 32 port - Free one power supply may be bad. never used, boots Brocade BR4100 - 32 port - Free working BR200e - 8/16 port - Free workingQLE2462, various vendors - Free: Low Profile bracket: 12 Full Height bracket: 2 Unused for a couple years, were working
QLE2464: 12 - Free Unused for a couple years, were working